DegronMD - Q9NRI5(DISC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G119W	TCGA-05-4417	LUAD	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.G119W	DO23570	LUAD	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.A205S	TCGA-A7-A26G	BRCA	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.A205S	DO4359	BRCA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.S293C	TCGA-AC-A23H	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.S293C	DO2401	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.D306N	TCGA-AG-A002	READ	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.25
p.A116T	TCGA-AP-A056	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.A116T	DO43971	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.G119E	TCGA-AP-A0LM	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.G119E	DO43306	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.G201D	TCGA-AX-A05Z	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6087
p.G201D	TCGA-DF-A2KU	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6087
p.G201D	DO233898	GACA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6087
p.G201D	DO40884	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6087
p.G201D	DO223286	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6087
p.P129T	TCGA-BG-A222	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2778
p.P129T	DO42977	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2778
p.G311V	TCGA-CN-4723	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.G311V	DO14830	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.S304Y	TCGA-D1-A17Q	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.S304Y	DO41903	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.T198I	TCGA-D3-A1Q4	SKCM	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7078
p.T198I	DO47631	SKCM	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7078
p.G201V	TCGA-D6-6823	HNSC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6421
p.G201V	DO14222	HNSC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6421
p.T198N	TCGA-DD-A1EJ	LIHC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7055
p.T198N	DO22994	LIHC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7055
p.V195I	TCGA-DF-A2KU	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.5965
p.V195I	DO223286	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.5965
p.G300V	TCGA-DX-A6YV	SARC	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6421
p.G300V	DO220011	SARC	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation altering degron motif	0.6421
p.P135L	TCGA-ER-A19K	SKCM	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.P135L	DO47672	SKCM	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1111
p.D130E	TCGA-ER-A19P	SKCM	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.25
p.D130E	DO47623	SKCM	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.25
p.L128F	TCGA-NC-A5HJ	LUSC	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.L128F	DO219189	LUSC	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.L128F	SIDM00720	Mesothelioma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.L128F	ACH-000648	Lung Cancer	CCLE	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.L128F	NCI-H28	pleura	COSMIC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.3056
p.P129S	TCGA-NC-A5HJ	LUSC	TCGA	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2778
p.P129S	DO219189	LUSC	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2778
p.R289S	TCGA-NJ-A4YF	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.R289S	DO218940	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.D298E	DO218159	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.3056
p.S293Y	DO8264	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1667
p.G137C	DO50319	ESAD	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.0556
p.F210I	DO234412	ESAD	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1111
p.G125D	DO222549	ESCA	ICGC	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.6087
p.P197Q	DO233881	GACA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.5924
p.C312F	DO228971	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0833
p.H292Y	DO229058	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1389
p.G201A	DO231086	LUSC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.6429
p.G192D	DO228138	PBCA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.25
p.A116V	SIDM00232	Kidney Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.A116V	SIDM01439	Hepatocellular Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.A116V	SIDM01753	Gastric Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.2222
p.R127T	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7876
p.R127T	ACH-000665	Lung Cancer	CCLE	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7876
p.R127T	SK-MES-1	lung	COSMIC	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7876
p.M291T	SIDM01002	Breast Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.M291T	ACH-000117	Breast Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.M291T	EFM-192A	breast	COSMIC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.1111
p.R289L	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.R289L	ACH-000488	Esophageal Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.R289L	TE-11	oesophagus	COSMIC	PGSSS	DEG_SPOP_SBC_1	299:303	Mutation rewiring degron network	0.0556
p.G124D	SIDM01145	Gastric Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7198
p.G124D	ACH-000581	Gastric Cancer	CCLE	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7198
p.G124D	NCI-SNU-16	stomach	COSMIC	IQLRGGTR	SCF_FBXL2	120:127	Mutation altering degron motif	0.7198
p.G190D	SIDM00537	Colorectal Carcinoma	GDSC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.G190D	ACH-000982	Colon/Colorectal Cancer	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.G190D	ACH-001345	Colon/Colorectal Cancer	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.G190D	GP5d	large intestine	COSMIC	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation rewiring degron network	0.1944
p.P199T	ACH-000160	Rhabdoid	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	195:202	Mutation altering degron motif	0.7031
p.K132I	NCI-SNU-5	stomach	COSMIC	IQLRGGTR	SCF_FBXL2	120:127	Mutation rewiring degron network	0.1944

Kaplan plot for DISC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DISC1

UniProt ID: Q9NRI5

Entrez ID: 27185

Protein name: Disrupted in schizophrenia 1 protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DISC1 in