DegronMD

Uniprot ID: Q9NRI5

Source protein: Disrupted in schizophrenia 1 protein

Source gene: DISC1

Class: SCF_FBXL2

Location: 120:127

E3 ligase: FBXL2

DEGRON score: 0.9945

ASA_SCORE: 69.6

COIL: 0.6758

CONS_SCORE: 0.4365

DSS_SCORE: 0.4212

HELIX: 0.0448

FCONS_SCORE: 1.2948

RIG_SCORE: 0.7376

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G119W	TCGA-05-4417	LUAD	TCGA	IQLRGGTR	SCF_FBXL2	0.3056
p.G119W	DO23570	LUAD	ICGC	IQLRGGTR	SCF_FBXL2	0.3056
p.A116T	TCGA-AP-A056	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	0.2222
p.A116T	DO43971	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	0.2222
p.G119E	TCGA-AP-A0LM	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	0.3056
p.G119E	DO43306	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	0.3056
p.P129T	TCGA-BG-A222	UCEC	TCGA	IQLRGGTR	SCF_FBXL2	0.2778
p.P129T	DO42977	UCEC	ICGC	IQLRGGTR	SCF_FBXL2	0.2778
p.P135L	TCGA-ER-A19K	SKCM	TCGA	IQLRGGTR	SCF_FBXL2	0.1111
p.P135L	DO47672	SKCM	ICGC	IQLRGGTR	SCF_FBXL2	0.1111
p.D130E	TCGA-ER-A19P	SKCM	TCGA	IQLRGGTR	SCF_FBXL2	0.25
p.D130E	DO47623	SKCM	ICGC	IQLRGGTR	SCF_FBXL2	0.25
p.L128F	TCGA-NC-A5HJ	LUSC	TCGA	IQLRGGTR	SCF_FBXL2	0.3056
p.L128F	DO219189	LUSC	ICGC	IQLRGGTR	SCF_FBXL2	0.3056
p.L128F	SIDM00720	Mesothelioma	GDSC	IQLRGGTR	SCF_FBXL2	0.3056
p.L128F	ACH-000648	Lung Cancer	CCLE	IQLRGGTR	SCF_FBXL2	0.3056
p.L128F	NCI-H28	pleura	COSMIC	IQLRGGTR	SCF_FBXL2	0.3056
p.P129S	TCGA-NC-A5HJ	LUSC	TCGA	IQLRGGTR	SCF_FBXL2	0.2778
p.P129S	DO219189	LUSC	ICGC	IQLRGGTR	SCF_FBXL2	0.2778
p.G137C	DO50319	ESAD	ICGC	IQLRGGTR	SCF_FBXL2	0.0556
p.G125D	DO222549	ESCA	ICGC	IQLRGGTR	SCF_FBXL2	0.6087
p.A116V	SIDM00232	Kidney Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	0.2222
p.A116V	SIDM01439	Hepatocellular Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	0.2222
p.A116V	SIDM01753	Gastric Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	0.2222
p.R127T	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	0.7876
p.R127T	ACH-000665	Lung Cancer	CCLE	IQLRGGTR	SCF_FBXL2	0.7876
p.R127T	SK-MES-1	lung	COSMIC	IQLRGGTR	SCF_FBXL2	0.7876
p.G124D	SIDM01145	Gastric Carcinoma	GDSC	IQLRGGTR	SCF_FBXL2	0.7198
p.G124D	ACH-000581	Gastric Cancer	CCLE	IQLRGGTR	SCF_FBXL2	0.7198
p.G124D	NCI-SNU-16	stomach	COSMIC	IQLRGGTR	SCF_FBXL2	0.7198
p.K132I	NCI-SNU-5	stomach	COSMIC	IQLRGGTR	SCF_FBXL2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IQLRGGTR

Degron related mutations and impact score

Drug responses associated with DISC1 mutations

All proteins holding degron of IQLRGGTR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRI5	Disrupted in schizophrenia 1 protein	SCF_FBXL2	120:127	IQLRGGTR	FBXL2	0.9945	More...