DegronMD

Uniprot ID: Q9NRI5

Source protein: Disrupted in schizophrenia 1 protein

Source gene: DISC1

Class: DEG_SCF_FBW7_1

Location: 195:202

E3 ligase: FBXW7

DEGRON score: 0.965

ASA_SCORE: 77.4625

COIL: 0.9469

CONS_SCORE: 0.407

DSS_SCORE: 0.5699

HELIX: 0.035

FCONS_SCORE: 0.9931

RIG_SCORE: 0.5636

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A205S	TCGA-A7-A26G	BRCA	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.25
p.A205S	DO4359	BRCA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.25
p.G201D	TCGA-AX-A05Z	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.6087
p.G201D	TCGA-DF-A2KU	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.6087
p.G201D	DO233898	GACA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.6087
p.G201D	DO40884	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.6087
p.G201D	DO223286	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.6087
p.T198I	TCGA-D3-A1Q4	SKCM	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.7078
p.T198I	DO47631	SKCM	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.7078
p.G201V	TCGA-D6-6823	HNSC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.6421
p.G201V	DO14222	HNSC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.6421
p.T198N	TCGA-DD-A1EJ	LIHC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.7055
p.T198N	DO22994	LIHC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.7055
p.V195I	TCGA-DF-A2KU	UCEC	TCGA	VPPTPPGS	DEG_SCF_FBW7_1	0.5965
p.V195I	DO223286	UCEC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.5965
p.F210I	DO234412	ESAD	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.1111
p.P197Q	DO233881	GACA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.5924
p.G201A	DO231086	LUSC	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.6429
p.G192D	DO228138	PBCA	ICGC	VPPTPPGS	DEG_SCF_FBW7_1	0.25
p.G190D	SIDM00537	Colorectal Carcinoma	GDSC	VPPTPPGS	DEG_SCF_FBW7_1	0.1944
p.G190D	ACH-000982	Colon/Colorectal Cancer	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	0.1944
p.G190D	ACH-001345	Colon/Colorectal Cancer	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	0.1944
p.G190D	GP5d	large_intestine	COSMIC	VPPTPPGS	DEG_SCF_FBW7_1	0.1944
p.P199T	ACH-000160	Rhabdoid	CCLE	VPPTPPGS	DEG_SCF_FBW7_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRI5	Disrupted in schizophrenia 1 protein	DEG_SCF_FBW7_1	195:202	VPPTPPGS	FBXW7	0.965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons