DegronMD

Uniprot ID: Q96RK0

Source protein: Protein capicua homolog

Source gene: CIC

Class: DEG_SPOP_SBC_1

Location: 1122:1126

E3 ligase: SPOP

DEGRON score: 0.879

ASA_SCORE: 87.06

COIL: 0.9498

CONS_SCORE: 0.4

DSS_SCORE: 0.4681

HELIX: 0.0146

FCONS_SCORE: 1.0541

RIG_SCORE: 0.6912

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1135L	TCGA-DU-6407	LGG	TCGA	VATST	DEG_SPOP_SBC_1	0.0833
p.P1135L	DO22295	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.0833
p.R1124W	DO222490	BTCA	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO223732	CESC	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO48508	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO50211	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO50147	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO50252	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO22163	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO22199	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO22315	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO223698	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1124W	DO44585	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.8634
p.R1122Q	DO222817	BTCA	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1122Q	DO40996	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1122Q	DO41199	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1130H	DO233634	GACA	ICGC	VATST	DEG_SPOP_SBC_1	0.2222
p.R1130H	DO38201	STAD	ICGC	VATST	DEG_SPOP_SBC_1	0.2222
p.R1130H	DO40808	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.2222
p.R1124Q	DO50238	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1124Q	DO50198	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1124Q	DO50156	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1124Q	DO22324	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.7329
p.R1124Q	ACH-000984	Endometrial/Uterine Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.7329
p.P1112L	DO50177	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.N1136I	DO50173	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.1667
p.P1112S	DO50146	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.P1112S	DO22109	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.0556
p.R1122P	DO50252	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.7512
p.F1119C	DO22496	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.25
p.N1114S	DO22443	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.1111
p.F1119L	DO48603	LGG	ICGC	VATST	DEG_SPOP_SBC_1	0.25
p.V1127F	DO228952	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.3056
p.S1125I	DO228971	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.7341
p.S1125I	DO229034	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.7341
p.R1130C	DO42280	UCEC	ICGC	VATST	DEG_SPOP_SBC_1	0.2222
p.A1125V	ACH-000942	Leukemia	CCLE	VATST	DEG_SPOP_SBC_1	0.6936
p.T1127P	ACH-000956	Prostate Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.3056
p.N1114D	ACH-000990	Endometrial/Uterine Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VATST

Degron related mutations and impact score

Drug responses associated with CIC mutations

All proteins holding degron of VATST