DegronMD

Uniprot ID: Q9HC84

Source protein: Mucin-5B

Source gene: MUC5B

Class: DEG_SPOP_SBC_1

Location: 1688:1692

E3 ligase: SPOP

DEGRON score: 0.9913

ASA_SCORE: 80.58

COIL: 0.7888

CONS_SCORE: 0.3574

DSS_SCORE: 0.6823

HELIX: 0.0268

FCONS_SCORE: 1.0085

RIG_SCORE: 0.716

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1690I	TCGA-91-6848	LUAD	TCGA	VATST	DEG_SPOP_SBC_1	0.7078
p.T1702M	TCGA-A5-A2K7	UCEC	TCGA	VATST	DEG_SPOP_SBC_1	0.0556
p.A1698T	TCGA-EB-A41A	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	0.1667
p.V1688M	TCGA-W3-AA1V	SKCM	TCGA	VATST	DEG_SPOP_SBC_1	0.7208
p.V1688A	DO233649	GACA	ICGC	VATST	DEG_SPOP_SBC_1	0.5825
p.P1689Q	DO50767	LICA	ICGC	VATST	DEG_SPOP_SBC_1	0.7035
p.T1693I	DO23846	LUAD	ICGC	VATST	DEG_SPOP_SBC_1	0.3056
p.P1689L	DO229459	SKCA	ICGC	VATST	DEG_SPOP_SBC_1	0.7582
p.A1701T	DO37429	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	0.0833
p.V1691M	DO51276	SKCM	ICGC	VATST	DEG_SPOP_SBC_1	0.7208
p.L1693F	SIDM00293	Small Cell Lung Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.3056
p.L1693F	ACH-002052	Lung Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.3056
p.L1693F	LU-139	lung	COSMIC	VATST	DEG_SPOP_SBC_1	0.3056
p.A1689S	SIDM01721	Non-Cancerous	GDSC	VATST	DEG_SPOP_SBC_1	0.6477
p.A1689S	SIDM00191	Kidney Carcinoma	GDSC	VATST	DEG_SPOP_SBC_1	0.6477
p.A1689S	ACH-002090	Kidney Cancer	CCLE	VATST	DEG_SPOP_SBC_1	0.6477
p.A1689S	ACH-002344	Non-Cancerous	CCLE	VATST	DEG_SPOP_SBC_1	0.6477

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00592	Podocalyxin	DEG_SPOP_SBC_1	134:138	VATST	SPOP	0.9934	More...
Q13105	Zinc finger and BTB domain-containing protein 17	DEG_SPOP_SBC_1	142:146	VATST	SPOP	0.6095	More...
Q14157	Ubiquitin-associated protein 2-like	DEG_SPOP_SBC_1	442:446	VATST	SPOP	0.9946	More...
Q5GH76	XK-related protein 4	DEG_SPOP_SBC_1	541:545	VATST	SPOP	0.7319	More...
Q8NFC6	Biorientation of chromosomes in cell division protein 1-like 1	DEG_SPOP_SBC_1	1517:1521	VATST	SPOP	0.9996	More...
Q92766	Ras-responsive element-binding protein 1	DEG_SPOP_SBC_1	519:523	VATST	SPOP	0.9773	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	1122:1126	VATST	SPOP	0.879	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1386:1390	VATST	SPOP	0.9581	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	1688:1692	VATST	SPOP	0.9913	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	310:314	VATST	SPOP	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons