DegronMD

Uniprot ID: Q8WZ64

Source protein: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2

Source gene: ARAP2

Class: DEG_SPOP_SBC_1

Location: 452:456

E3 ligase: SPOP

DEGRON score: 0.8986

ASA_SCORE: 81.66

COIL: 0.9044

CONS_SCORE: 0.371

DSS_SCORE: 0.448

HELIX: 0.0468

FCONS_SCORE: 1.1914

RIG_SCORE: 0.6533

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V446I	TCGA-19-5956	GBM	TCGA	PLSST	DEG_SPOP_SBC_1	0.1667
p.V446I	DO13863	GBM	ICGC	PLSST	DEG_SPOP_SBC_1	0.1667
p.V446I	SIDM01117	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.V446I	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.V446I	SIDM00150	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.V465I	TCGA-FU-A3HZ	CESC	TCGA	PLSST	DEG_SPOP_SBC_1	0.0833
p.V465I	DO6308	CESC	ICGC	PLSST	DEG_SPOP_SBC_1	0.0833
p.S445C	TCGA-WE-A8K4	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.1389
p.S445C	DO51281	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.1389
p.A460D	DO229019	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.R448M	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.2222
p.R448M	ACH-000924	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.2222
p.R448M	NCI-H2172	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	0.2222
p.I442N	SIDM00488	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	SIDM00008	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	SIDM01619	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	ACH-000796	Ovarian Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	ACH-000984	Endometrial/Uterine Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	ACH-001513	Cervical Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.0556
p.I442N	ACH-002345	Colon/Colorectal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.0556
p.D444Y	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1111
p.D444Y	ACH-000158	Lymphoma	CCLE	PLSST	DEG_SPOP_SBC_1	0.1111
p.S445F	ACH-002396	Bone Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.1389
p.S445F	Sarc9371	bone	COSMIC	PLSST	DEG_SPOP_SBC_1	0.1389
p.D454N	639-V	urinary_tract	COSMIC	PLSST	DEG_SPOP_SBC_1	0.6932
p.T445M	VM-CUB-1	urinary_tract	COSMIC	PLSST	DEG_SPOP_SBC_1	0.1389
p.T461I	NCI-H1793	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	659:663	PLSST	SPOP	0.9969	More...
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SPOP_SBC_1	852:856	PLSST	SPOP	0.9413	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	371:375	PLSST	SPOP	0.9973	More...
P58107	Epiplakin	DEG_SPOP_SBC_1	797:801	PLSST	SPOP	0.7149	More...
Q13873	Bone morphogenetic protein receptor type-2	DEG_SPOP_SBC_1	698:702	PLSST	SPOP	0.9891	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	320:324	PLSST	SPOP	0.9988	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	891:895	PLSST	SPOP	0.9403	More...
Q49AJ0	Protein FAM135B	DEG_SPOP_SBC_1	643:647	PLSST	SPOP	0.9487	More...
Q5M775	Cytospin-B	DEG_SPOP_SBC_1	342:346	PLSST	SPOP	0.9835	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_SPOP_SBC_1	1123:1127	PLSST	SPOP	0.9913	More...
Q69YN4	Protein virilizer homolog	DEG_SPOP_SBC_1	1757:1761	PLSST	SPOP	0.9993	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	336:340	PLSST	SPOP	0.984	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1665:1669	PLSST	SPOP	0.9861	More...
Q8IW45	ATP-dependent	DEG_SPOP_SBC_1	63:67	PLSST	SPOP	0.9107	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1684:1688	PLSST	SPOP	0.9408	More...
Q92546	RAB6A-GEF complex partner protein 2	DEG_SPOP_SBC_1	306:310	PLSST	SPOP	0.6123	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	393:397	PLSST	SPOP	0.9714	More...
Q96PX1	E3 ubiquitin ligase RNF157	DEG_SPOP_SBC_1	499:503	PLSST	SPOP	0.976	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	71:75	PLSST	SPOP	0.9941	More...
Q9NR46	Endophilin-B2	DEG_SPOP_SBC_1	295:299	PLSST	SPOP	0.6401	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	1908:1912	PLSST	SPOP	0.9775	More...
Q9Y2W1	Thyroid hormone receptor-associated protein 3	DEG_SPOP_SBC_1	276:280	PLSST	SPOP	0.9859	More...
Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	DEG_SPOP_SBC_1	40:44	PLSST	SPOP	0.9797	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	452:456	PLSST	SPOP	0.8986	More...
Q9Y5F7	Protocadherin gamma-C4	DEG_SPOP_SBC_1	544:548	PLSST	SPOP	0.8845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSST

Degron related mutations and impact score

Drug responses associated with ARAP2 mutations

All proteins holding degron of PLSST