DegronMD - P58107(EPPK1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1158W	TCGA-5M-AAT6	COAD	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.7523
p.R1158W	DO223703	COAD	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.7523
p.R1158W	DO234462	ESAD	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.7523
p.T791M	TCGA-AD-5900	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	797:801	Mutation blocking phosphorylation signal	0.6111
p.T791M	DO8514	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation blocking phosphorylation signal	0.6111
p.T791M	DO233767	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation blocking phosphorylation signal	0.6111
p.E1163D	TCGA-AX-A2HC	UCEC	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.5647
p.E1163D	DO41572	UCEC	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.5647
p.A809T	TCGA-BR-4368	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1111
p.A809T	DO38715	STAD	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1111
p.P789L	TCGA-EE-A2MD	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1111
p.P789L	DO222434	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1111
p.P789L	DO37851	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1111
p.R1158L	TCGA-ER-A19C	SKCM	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.7316
p.R1158L	DO47353	SKCM	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.7316
p.E1163Q	TCGA-GV-A3JZ	BLCA	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.5633
p.E1163Q	DO773	BLCA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.5633
p.R1158Q	TCGA-WE-AAA3	SKCM	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.6218
p.R1158Q	DO230343	COCA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.6218
p.R1158Q	DO51295	SKCM	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.6218
p.E790K	DO233272	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.1389
p.V1165M	DO233700	GACA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation altering degron motif	0.6097
p.C1151F	DO32872	PACA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.1389
p.P804S	SIDM00793	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.25
p.Q1157H	SIDM00118	Colorectal Carcinoma	GDSC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.3056
p.S1149N	SIDM00150	Colorectal Carcinoma	GDSC	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.0833
p.S1149N	ACH-000969	Colon/Colorectal Cancer	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.0833
p.D788A	ACH-000548	Head and Neck Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.0833
p.D788A	ACH-001578	Embryonal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	797:801	Mutation rewiring degron network	0.0833
p.P1173Q	ACH-001134	Lymphoma	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.1389
p.Q1174H	ACH-001796	Liposarcoma	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	1158:1166	Mutation rewiring degron network	0.1111

Kaplan plot for EPPK1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPPK1

UniProt ID: P58107

Entrez ID: 83481

Protein name: Epiplakin (450 kDa epidermal antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPPK1 in