DegronMD

Uniprot ID: P58107

Source protein: Epiplakin

Source gene: EPPK1

Class: DEG_APCC_DBOX_1

Location: 1158:1166

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6004

ASA_SCORE: 73.5444

COIL: 0.2327

CONS_SCORE: 0.7032

DSS_SCORE: 0.417

HELIX: 0.7427

FCONS_SCORE: 1.0496

RIG_SCORE: 0.78

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1158W	TCGA-5M-AAT6	COAD	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	0.7523
p.R1158W	DO223703	COAD	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.7523
p.R1158W	DO234462	ESAD	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.7523
p.E1163D	TCGA-AX-A2HC	UCEC	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	0.5647
p.E1163D	DO41572	UCEC	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.5647
p.R1158L	TCGA-ER-A19C	SKCM	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	0.7316
p.R1158L	DO47353	SKCM	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.7316
p.E1163Q	TCGA-GV-A3JZ	BLCA	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	0.5633
p.E1163Q	DO773	BLCA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.5633
p.R1158Q	TCGA-WE-AAA3	SKCM	TCGA	RRGLLEDVQ	DEG_APCC_DBOX_1	0.6218
p.R1158Q	DO230343	COCA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.6218
p.R1158Q	DO51295	SKCM	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.6218
p.V1165M	DO233700	GACA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.6097
p.C1151F	DO32872	PACA	ICGC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.1389
p.Q1157H	SIDM00118	Colorectal Carcinoma	GDSC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.3056
p.S1149N	SIDM00150	Colorectal Carcinoma	GDSC	RRGLLEDVQ	DEG_APCC_DBOX_1	0.0833
p.S1149N	ACH-000969	Colon/Colorectal Cancer	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	0.0833
p.P1173Q	ACH-001134	Lymphoma	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	0.1389
p.Q1174H	ACH-001796	Liposarcoma	CCLE	RRGLLEDVQ	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58107	Epiplakin	DEG_APCC_DBOX_1	1158:1166	RRGLLEDVQ	APC,CDC20,FZR1	0.6004	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons