DegronMD

Uniprot ID: O15550

Source protein: Lysine-specific demethylase 6A

Source gene: KDM6A

Class: DEG_SPOP_SBC_1

Location: 659:663

E3 ligase: SPOP

DEGRON score: 0.9969

ASA_SCORE: 76

COIL: 0.929

CONS_SCORE: 0.2707

DSS_SCORE: 0.8441

HELIX: 0.03

FCONS_SCORE: 1.0691

RIG_SCORE: 0.5344

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q667K	TCGA-ER-A19H	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.2222
p.Q667K	DO47299	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.Q670R	DO222427	BTCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.1389
p.A671E	DO50681	ORCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	SIDM00845	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	SIDM01519	Head and Neck Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	ACH-000786	Lymphoma	CCLE	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.1111
p.S651L	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.1111
p.G653D	ACH-000353	Esophageal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	0.1667
p.H664Q	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.3056
p.H664Q	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.3056
p.I673T	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.0556
p.I673T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.0556
p.I655T	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.2222
p.I655T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	659:663	PLSST	SPOP	0.9969	More...
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SPOP_SBC_1	852:856	PLSST	SPOP	0.9413	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	371:375	PLSST	SPOP	0.9973	More...
P58107	Epiplakin	DEG_SPOP_SBC_1	797:801	PLSST	SPOP	0.7149	More...
Q13873	Bone morphogenetic protein receptor type-2	DEG_SPOP_SBC_1	698:702	PLSST	SPOP	0.9891	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	320:324	PLSST	SPOP	0.9988	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	891:895	PLSST	SPOP	0.9403	More...
Q49AJ0	Protein FAM135B	DEG_SPOP_SBC_1	643:647	PLSST	SPOP	0.9487	More...
Q5M775	Cytospin-B	DEG_SPOP_SBC_1	342:346	PLSST	SPOP	0.9835	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_SPOP_SBC_1	1123:1127	PLSST	SPOP	0.9913	More...
Q69YN4	Protein virilizer homolog	DEG_SPOP_SBC_1	1757:1761	PLSST	SPOP	0.9993	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	336:340	PLSST	SPOP	0.984	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1665:1669	PLSST	SPOP	0.9861	More...
Q8IW45	ATP-dependent	DEG_SPOP_SBC_1	63:67	PLSST	SPOP	0.9107	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1684:1688	PLSST	SPOP	0.9408	More...
Q92546	RAB6A-GEF complex partner protein 2	DEG_SPOP_SBC_1	306:310	PLSST	SPOP	0.6123	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	393:397	PLSST	SPOP	0.9714	More...
Q96PX1	E3 ubiquitin ligase RNF157	DEG_SPOP_SBC_1	499:503	PLSST	SPOP	0.976	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	71:75	PLSST	SPOP	0.9941	More...
Q9NR46	Endophilin-B2	DEG_SPOP_SBC_1	295:299	PLSST	SPOP	0.6401	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	1908:1912	PLSST	SPOP	0.9775	More...
Q9Y2W1	Thyroid hormone receptor-associated protein 3	DEG_SPOP_SBC_1	276:280	PLSST	SPOP	0.9859	More...
Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	DEG_SPOP_SBC_1	40:44	PLSST	SPOP	0.9797	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	452:456	PLSST	SPOP	0.8986	More...
Q9Y5F7	Protocadherin gamma-C4	DEG_SPOP_SBC_1	544:548	PLSST	SPOP	0.8845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSST

Degron related mutations and impact score

Drug responses associated with KDM6A mutations

All proteins holding degron of PLSST