DegronMD - Q5VVH5(IRAK1BP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R51S	TCGA-86-7701	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.R51S	DO24441	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.P35S	TCGA-AR-A2LL	BRCA	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.5641
p.P35S	TCGA-EO-A3KX	UCEC	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.5641
p.P35S	DO1702	BRCA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.5641
p.P35S	DO219774	UCEC	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.5641
p.T50I	TCGA-AX-A05Y	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1667
p.T50I	DO42897	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1667
p.T50I	ACH-001842	Bile Duct Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1667
p.R31I	TCGA-C5-A1M7	CESC	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.8102
p.R31I	DO48981	CESC	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.8102
p.R21Q	TCGA-CG-5721	STAD	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.R21Q	DO38192	STAD	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47P	TCGA-GV-A40E	BLCA	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47P	TCGA-GV-A40E	BLCA	TCGA	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47P	DO526	BLCA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47P	DO526	BLCA	ICGC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q54R	DO234320	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.R21W	DO228912	LICA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.R23Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1389
p.R23Q	NCI-H1648	lung	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1389
p.Q47E	SIDM01145	Gastric Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	SIDM01145	Gastric Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47E	SIDM00612	Glioma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	SIDM00612	Glioma	GDSC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47E	SIDM01494	Glioblastoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	SIDM01494	Glioblastoma	GDSC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47E	SIDM01448	Head and Neck Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	SIDM01448	Head and Neck Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47E	KINGS-1	central nervous system	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	KINGS-1	central nervous system	COSMIC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.Q47E	NCI-SNU-16	stomach	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.0833
p.Q47E	NCI-SNU-16	stomach	COSMIC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.H39N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.3056
p.H39N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056
p.R38C	ACH-001573	Leukemia	CCLE	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.719
p.A34V	HCT-15	large intestine	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation altering degron motif	0.6936
p.A39V	NCI-H630	large intestine	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.3056
p.A39V	NCI-H630	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056
p.V41I	SNU-1040	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.7076
p.T25K	NCI-H748	lung	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	30:38	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRAK1BP1

UniProt ID: Q5VVH5

Entrez ID: 134728

Protein name: Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1-binding protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRAK1BP1 in