DegronMD

Uniprot ID: Q5VVH5

Source protein: Interleukin-1 receptor-associated kinase 1-binding protein 1

Source gene: IRAK1BP1

Class: DEG_APCC_DBOX_1

Location: 30:38

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9963

ASA_SCORE: 81.7222

COIL: 0.762

CONS_SCORE: 0.3018

DSS_SCORE: 0.6224

HELIX: 0.1352

FCONS_SCORE: 1.096

RIG_SCORE: 0.6709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P35S	TCGA-AR-A2LL	BRCA	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	0.5641
p.P35S	TCGA-EO-A3KX	UCEC	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	0.5641
p.P35S	DO1702	BRCA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.5641
p.P35S	DO219774	UCEC	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.5641
p.R31I	TCGA-C5-A1M7	CESC	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	0.8102
p.R31I	DO48981	CESC	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.8102
p.R21Q	TCGA-CG-5721	STAD	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.R21Q	DO38192	STAD	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47P	TCGA-GV-A40E	BLCA	TCGA	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47P	DO526	BLCA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.R21W	DO228912	LICA	ICGC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.R23Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.1389
p.R23Q	NCI-H1648	lung	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.1389
p.Q47E	SIDM01145	Gastric Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47E	SIDM00612	Glioma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47E	SIDM01494	Glioblastoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47E	SIDM01448	Head and Neck Carcinoma	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47E	KINGS-1	central_nervous_system	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.Q47E	NCI-SNU-16	stomach	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.0833
p.H39N	SIDM01263	T-Lymphoblastic Leukemia	GDSC	GRETLPGLR	DEG_APCC_DBOX_1	0.3056
p.R38C	ACH-001573	Leukemia	CCLE	GRETLPGLR	DEG_APCC_DBOX_1	0.719
p.A34V	HCT-15	large_intestine	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.6936
p.A39V	NCI-H630	large_intestine	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.3056
p.T25K	NCI-H748	lung	COSMIC	GRETLPGLR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	DEG_APCC_DBOX_1	30:38	GRETLPGLR	APC,CDC20,FZR1	0.9963	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons