DegronMD - Q5M775(SPECC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P814S	TCGA-36-2538	OV	TCGA	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation altering degron motif	0.5641
p.P814S	DO28018	OV	ICGC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation altering degron motif	0.5641
p.D886Y	TCGA-85-A53L	LUSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.6214
p.D886Y	DO45459	LUSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.6214
p.R102L	TCGA-A5-A1OF	UCEC	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.R102L	DO42568	UCEC	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.A859T	TCGA-AJ-A2QO	UCEC	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation altering degron motif	0.6028
p.A859T	DO42177	UCEC	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation altering degron motif	0.6028
p.S893L	TCGA-AO-A129	BRCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.S893L	TCGA-MV-A51V	BLCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.S893L	DO474	BLCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.S893L	DO3910	BRCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.E332K	TCGA-AP-A056	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.0556
p.E332K	DO43971	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.0556
p.R867S	TCGA-AP-A1DV	UCEC	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.2778
p.R867S	DO43186	UCEC	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.2778
p.A877T	TCGA-AP-A1DV	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1667
p.A877T	DO43186	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1667
p.E901D	TCGA-AX-A0J0	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.0556
p.E901D	DO41133	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.0556
p.L849Q	TCGA-BP-4964	KIRC	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.7765
p.L849Q	DO16263	KIRC	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.7765
p.T86M	TCGA-CD-A4MJ	STAD	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.T86M	TCGA-L5-A4OI	ESCA	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.T86M	TCGA-L5-A8NW	ESCA	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.T86M	DO47811	STAD	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0556
p.G851W	TCGA-D3-A2JC	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.G851W	TCGA-EE-A2MJ	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.G851W	TCGA-ER-A19G	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.G851W	DO47284	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.G851W	DO47578	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.G851W	DO38099	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6714
p.R875Q	TCGA-D5-6927	COAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875Q	TCGA-D5-6927	COAD	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.R875Q	DO10332	COAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875Q	DO10332	COAD	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.P891H	TCGA-D6-6823	HNSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.6583
p.P891H	DO14222	HNSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.6583
p.R884C	TCGA-DG-A2KL	CESC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.8301
p.R884C	DO51596	CESC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.8301
p.R884C	SIDM02039	Colorectal Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation altering degron motif	0.8301
p.Q837H	TCGA-EE-A20C	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.1111
p.Q837H	DO47665	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.1111
p.I839V	TCGA-EO-A22U	UCEC	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.1667
p.I839V	DO43755	UCEC	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.1667
p.L896I	TCGA-EO-A3B0	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1944
p.L896I	DO219773	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1944
p.T100S	TCGA-EP-A2KA	LIHC	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6005
p.T100S	DO23023	LIHC	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6005
p.G836V	TCGA-ER-A19G	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.0833
p.G836V	DO47284	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.0833
p.V862F	TCGA-ER-A19P	SKCM	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation altering degron motif	0.7068
p.V862F	DO47623	SKCM	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation altering degron motif	0.7068
p.S345P	TCGA-FI-A2D5	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	342:346	Mutation altering degron motif	0.6752
p.S345P	DO41331	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation altering degron motif	0.6752
p.K351R	TCGA-G3-AAUZ	LIHC	TCGA	PLSST	DEG_SPOP_SBC_1	342:346	Mutation blocking ubiquitination signal	0.6389
p.K351R	DO52293	LIHC	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation blocking ubiquitination signal	0.6389
p.G880W	TCGA-GN-A26C	SKCM	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.25
p.G880W	DO37782	SKCM	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.25
p.S872I	TCGA-IB-7651	PAAD	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.1389
p.S872I	DO46657	PAAD	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.1389
p.V881A	TCGA-IB-7651	PAAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.V881A	DO46657	PAAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.2778
p.S872N	TCGA-R5-A7ZI	STAD	TCGA	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.1389
p.S872N	DO222342	STAD	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.1389
p.E87G	TCGA-RC-A7SH	LIHC	TCGA	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.E87G	DO52312	LIHC	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.F337L	DO219041	BLCA	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.1944
p.R109W	DO222919	BTCA	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.E353V	DO44096	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.1389
p.I349V	DO10276	COAD	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.25
p.R89C	DO222874	COCA	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.R89H	DO233646	GACA	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.R89H	SIDM00803	Kidney Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.R89H	769-P	kidney	COSMIC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.1389
p.T339M	DO14097	GBM	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.25
p.H348N	DO14174	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2778
p.V862G	DO18164	KIRC	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation altering degron motif	0.7532
p.R94L	DO20917	KIRP	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.R875W	DO228916	LICA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875W	DO228916	LICA	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.R875W	SIDM01617	Endometrial Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875W	SIDM01617	Endometrial Carcinoma	GDSC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.R875W	ACH-000994	Endometrial/Uterine Cancer	CCLE	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875W	ACH-000994	Endometrial/Uterine Cancer	CCLE	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.E332D	DO228985	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.0556
p.K825M	DO232025	LICA	ICGC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation substituting flanking lysine	0.1944
p.W801L	DO229028	LICA	ICGC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation rewiring degron network	0.0556
p.T346N	DO50836	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation altering degron motif	0.7055
p.P350S	DO50970	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.S878I	DO23112	LINC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1944
p.C805F	DO50785	LIRI	ICGC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation rewiring degron network	0.1667
p.E353K	DO229177	LMS	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.1389
p.G95R	DO52686	MALY	ICGC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.3056
p.R875P	DO229459	SKCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation rewiring degron network	0.1111
p.R875P	DO229459	SKCA	ICGC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.0556
p.P350T	DO37627	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.I852R	DO229218	THCA	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.8102
p.T99S	SIDM01722	Non-Cancerous	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6005
p.T99S	SIDM00174	Head and Neck Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6005
p.T99S	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.6005
p.K354M	SIDM01194	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	342:346	Mutation substituting flanking lysine	0.2222
p.T94R	SIDM00562	Breast Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.T94R	ACH-002163	Breast Cancer	CCLE	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.T94R	MRK-nu-1	breast	COSMIC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.2778
p.H842R	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.25
p.H842R	ACH-000305	Esophageal Cancer	CCLE	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.25
p.H842R	EC-GI-10	oesophagus	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.25
p.G93S	SIDM00483	Esophageal Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.G93S	ACH-001654	Esophageal Cancer	CCLE	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.G93S	SK-GT-4	oesophagus	COSMIC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.25
p.A817T	SIDM01608	Endometrial Carcinoma	GDSC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation rewiring degron network	0.3056
p.A817T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation rewiring degron network	0.3056
p.S810Y	ACH-001999	Pancreatic Cancer	CCLE	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation blocking phosphorylation signal	0.75
p.V96D	CW-2	large intestine	COSMIC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation altering degron motif	0.7785
p.P826S	G-361	skin	COSMIC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation blocking phosphorylation signal	0.5
p.S109C	COR-L279	lung	COSMIC	AFTTT	DEG_SPOP_SBC_1	96:100	Mutation rewiring degron network	0.0833
p.P826L	G-361	skin	COSMIC	PTPPES	DEG_SCF_FBW7_1	811:816	Mutation blocking phosphorylation signal	0.5
p.E867K	JSC-1	haematopoietic and lymphoid tissue	COSMIC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation rewiring degron network	0.2778
p.P841L	Mewo	skin	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation rewiring degron network	0.2222
p.F845L	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	845:853	Mutation altering degron motif	0.6981
p.A873V	SNU-175	large intestine	COSMIC	QRLDLPDLP	DEG_APCC_DBOX_1	883:891	Mutation blocking phosphorylation signal	0.5
p.A873V	SNU-175	large intestine	COSMIC	APAAAVSPM	DEG_SIAH_1	857:865	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPECC1

UniProt ID: Q5M775

Entrez ID: 92521

Protein name: Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPECC1 in