DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_APCC_DBOX_1

Location: 845:853

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9985

ASA_SCORE: 85.4778

COIL: 0.926

CONS_SCORE: 0.5045

DSS_SCORE: 0.5711

HELIX: 0.0327

FCONS_SCORE: 1.3294

RIG_SCORE: 0.6504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L849Q	TCGA-BP-4964	KIRC	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.7765
p.L849Q	DO16263	KIRC	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.7765
p.G851W	TCGA-D3-A2JC	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.G851W	TCGA-EE-A2MJ	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.G851W	TCGA-ER-A19G	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.G851W	DO47284	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.G851W	DO47578	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.G851W	DO38099	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.6714
p.Q837H	TCGA-EE-A20C	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.1111
p.Q837H	DO47665	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.1111
p.I839V	TCGA-EO-A22U	UCEC	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.1667
p.I839V	DO43755	UCEC	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.1667
p.G836V	TCGA-ER-A19G	SKCM	TCGA	PRSPLSGIP	DEG_APCC_DBOX_1	0.0833
p.G836V	DO47284	SKCM	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.0833
p.I852R	DO229218	THCA	ICGC	PRSPLSGIP	DEG_APCC_DBOX_1	0.8102
p.H842R	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PRSPLSGIP	DEG_APCC_DBOX_1	0.25
p.H842R	ACH-000305	Esophageal Cancer	CCLE	PRSPLSGIP	DEG_APCC_DBOX_1	0.25
p.H842R	EC-GI-10	oesophagus	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	0.25
p.P841L	Mewo	skin	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	0.2222
p.F845L	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSPLSGIP	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_APCC_DBOX_1	845:853	PRSPLSGIP	APC,CDC20,FZR1	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons