DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_APCC_DBOX_1

Location: 883:891

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8315

ASA_SCORE: 92.9778

COIL: 0.8919

CONS_SCORE: 0.3598

DSS_SCORE: 0.4817

HELIX: 0.0662

FCONS_SCORE: 0.999

RIG_SCORE: 0.748

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D886Y	TCGA-85-A53L	LUSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.6214
p.D886Y	DO45459	LUSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.6214
p.S893L	TCGA-AO-A129	BRCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	TCGA-MV-A51V	BLCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	DO474	BLCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	DO3910	BRCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.A877T	TCGA-AP-A1DV	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1667
p.A877T	DO43186	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1667
p.E901D	TCGA-AX-A0J0	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.0556
p.E901D	DO41133	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.0556
p.R875Q	TCGA-D5-6927	COAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875Q	DO10332	COAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.P891H	TCGA-D6-6823	HNSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.6583
p.P891H	DO14222	HNSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.6583
p.R884C	TCGA-DG-A2KL	CESC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.R884C	DO51596	CESC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.R884C	SIDM02039	Colorectal Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.L896I	TCGA-EO-A3B0	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.L896I	DO219773	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.G880W	TCGA-GN-A26C	SKCM	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.25
p.G880W	DO37782	SKCM	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.25
p.V881A	TCGA-IB-7651	PAAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.V881A	DO46657	PAAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.R875W	DO228916	LICA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875W	SIDM01617	Endometrial Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875W	ACH-000994	Endometrial/Uterine Cancer	CCLE	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.S878I	DO23112	LINC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.R875P	DO229459	SKCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.A873V	SNU-175	large_intestine	COSMIC	QRLDLPDLP	DEG_APCC_DBOX_1	0.5

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRLDLPDLP

Degron related mutations and impact score

Drug responses associated with SPECC1 mutations

All proteins holding degron of QRLDLPDLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_APCC_DBOX_1	883:891	QRLDLPDLP	APC,CDC20,FZR1	0.8315	More...