DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_APCC_DBOX_1

Location: 883:891

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8315

ASA_SCORE: 92.9778

COIL: 0.8919

CONS_SCORE: 0.3598

DSS_SCORE: 0.4817

HELIX: 0.0662

FCONS_SCORE: 0.999

RIG_SCORE: 0.748

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R884C	TCGA-DG-A2KL	CESC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.R884C	DO51596	CESC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.R884C	SIDM02039	Colorectal Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	0.8301
p.P891H	TCGA-D6-6823	HNSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.6583
p.P891H	DO14222	HNSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.6583
p.D886Y	TCGA-85-A53L	LUSC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.6214
p.D886Y	DO45459	LUSC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.6214
p.A873V	SNU-175	large_intestine	COSMIC	QRLDLPDLP	DEG_APCC_DBOX_1	0.5
p.S893L	TCGA-AO-A129	BRCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	TCGA-MV-A51V	BLCA	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	DO474	BLCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.S893L	DO3910	BRCA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.V881A	TCGA-IB-7651	PAAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.V881A	DO46657	PAAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.2778
p.G880W	TCGA-GN-A26C	SKCM	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.25
p.G880W	DO37782	SKCM	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.25
p.L896I	TCGA-EO-A3B0	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.L896I	DO219773	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.S878I	DO23112	LINC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1944
p.A877T	TCGA-AP-A1DV	UCEC	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1667
p.A877T	DO43186	UCEC	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1667
p.R875Q	TCGA-D5-6927	COAD	TCGA	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875Q	DO10332	COAD	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875W	DO228916	LICA	ICGC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111
p.R875W	SIDM01617	Endometrial Carcinoma	GDSC	QRLDLPDLP	DEG_APCC_DBOX_1	0.1111

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_APCC_DBOX_1	883:891	QRLDLPDLP	APC,CDC20,FZR1	0.8315	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons