DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_SCF_FBW7_1

Location: 811:816

E3 ligase: FBXW7

DEGRON score: 0.9975

ASA_SCORE: 97.05

COIL: 0.9252

CONS_SCORE: 0.3585

DSS_SCORE: 0.5534

HELIX: 0.0392

FCONS_SCORE: 0.8426

RIG_SCORE: 0.637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P814S	TCGA-36-2538	OV	TCGA	PTPPES	DEG_SCF_FBW7_1	0.5641
p.P814S	DO28018	OV	ICGC	PTPPES	DEG_SCF_FBW7_1	0.5641
p.K825M	DO232025	LICA	ICGC	PTPPES	DEG_SCF_FBW7_1	0.1944
p.W801L	DO229028	LICA	ICGC	PTPPES	DEG_SCF_FBW7_1	0.0556
p.C805F	DO50785	LIRI	ICGC	PTPPES	DEG_SCF_FBW7_1	0.1667
p.A817T	SIDM01608	Endometrial Carcinoma	GDSC	PTPPES	DEG_SCF_FBW7_1	0.3056
p.A817T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPES	DEG_SCF_FBW7_1	0.3056
p.S810Y	ACH-001999	Pancreatic Cancer	CCLE	PTPPES	DEG_SCF_FBW7_1	0.75
p.P826S	G-361	skin	COSMIC	PTPPES	DEG_SCF_FBW7_1	0.5
p.P826L	G-361	skin	COSMIC	PTPPES	DEG_SCF_FBW7_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_SCF_FBW7_1	811:816	PTPPES	FBXW7	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons