DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_SPOP_SBC_1

Location: 96:100

E3 ligase: SPOP

DEGRON score: 0.9946

ASA_SCORE: 81.82

COIL: 0.8546

CONS_SCORE: 0.3525

DSS_SCORE: 0.6006

HELIX: 0.0504

FCONS_SCORE: 0.9713

RIG_SCORE: 0.7323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R102L	TCGA-A5-A1OF	UCEC	TCGA	AFTTT	DEG_SPOP_SBC_1	0.2778
p.R102L	DO42568	UCEC	ICGC	AFTTT	DEG_SPOP_SBC_1	0.2778
p.T86M	TCGA-CD-A4MJ	STAD	TCGA	AFTTT	DEG_SPOP_SBC_1	0.0556
p.T86M	TCGA-L5-A4OI	ESCA	TCGA	AFTTT	DEG_SPOP_SBC_1	0.0556
p.T86M	TCGA-L5-A8NW	ESCA	TCGA	AFTTT	DEG_SPOP_SBC_1	0.0556
p.T86M	DO47811	STAD	ICGC	AFTTT	DEG_SPOP_SBC_1	0.0556
p.T100S	TCGA-EP-A2KA	LIHC	TCGA	AFTTT	DEG_SPOP_SBC_1	0.6005
p.T100S	DO23023	LIHC	ICGC	AFTTT	DEG_SPOP_SBC_1	0.6005
p.E87G	TCGA-RC-A7SH	LIHC	TCGA	AFTTT	DEG_SPOP_SBC_1	0.0833
p.E87G	DO52312	LIHC	ICGC	AFTTT	DEG_SPOP_SBC_1	0.0833
p.R109W	DO222919	BTCA	ICGC	AFTTT	DEG_SPOP_SBC_1	0.0833
p.R89C	DO222874	COCA	ICGC	AFTTT	DEG_SPOP_SBC_1	0.1389
p.R89H	DO233646	GACA	ICGC	AFTTT	DEG_SPOP_SBC_1	0.1389
p.R89H	SIDM00803	Kidney Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	0.1389
p.R89H	769-P	kidney	COSMIC	AFTTT	DEG_SPOP_SBC_1	0.1389
p.R94L	DO20917	KIRP	ICGC	AFTTT	DEG_SPOP_SBC_1	0.2778
p.G95R	DO52686	MALY	ICGC	AFTTT	DEG_SPOP_SBC_1	0.3056
p.T99S	SIDM01722	Non-Cancerous	GDSC	AFTTT	DEG_SPOP_SBC_1	0.6005
p.T99S	SIDM00174	Head and Neck Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	0.6005
p.T99S	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	0.6005
p.T94R	SIDM00562	Breast Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	0.2778
p.T94R	ACH-002163	Breast Cancer	CCLE	AFTTT	DEG_SPOP_SBC_1	0.2778
p.T94R	MRK-nu-1	breast	COSMIC	AFTTT	DEG_SPOP_SBC_1	0.2778
p.G93S	SIDM00483	Esophageal Carcinoma	GDSC	AFTTT	DEG_SPOP_SBC_1	0.25
p.G93S	ACH-001654	Esophageal Cancer	CCLE	AFTTT	DEG_SPOP_SBC_1	0.25
p.G93S	SK-GT-4	oesophagus	COSMIC	AFTTT	DEG_SPOP_SBC_1	0.25
p.V96D	CW-2	large_intestine	COSMIC	AFTTT	DEG_SPOP_SBC_1	0.7785
p.S109C	COR-L279	lung	COSMIC	AFTTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_SPOP_SBC_1	96:100	AFTTT	SPOP	0.9946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AFTTT

Degron related mutations and impact score

Drug responses associated with SPECC1 mutations

All proteins holding degron of AFTTT