DegronMD

Uniprot ID: Q5M775

Source protein: Cytospin-B

Source gene: SPECC1

Class: DEG_SIAH_1

Location: 857:865

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9954

ASA_SCORE: 74.3556

COIL: 0.8139

CONS_SCORE: 0.4211

DSS_SCORE: 0.5507

HELIX: 0.126

FCONS_SCORE: 0.9779

RIG_SCORE: 0.6748

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A859T	TCGA-AJ-A2QO	UCEC	TCGA	APAAAVSPM	DEG_SIAH_1	0.6028
p.A859T	DO42177	UCEC	ICGC	APAAAVSPM	DEG_SIAH_1	0.6028
p.R867S	TCGA-AP-A1DV	UCEC	TCGA	APAAAVSPM	DEG_SIAH_1	0.2778
p.R867S	DO43186	UCEC	ICGC	APAAAVSPM	DEG_SIAH_1	0.2778
p.R875Q	TCGA-D5-6927	COAD	TCGA	APAAAVSPM	DEG_SIAH_1	0.0556
p.R875Q	DO10332	COAD	ICGC	APAAAVSPM	DEG_SIAH_1	0.0556
p.V862F	TCGA-ER-A19P	SKCM	TCGA	APAAAVSPM	DEG_SIAH_1	0.7068
p.V862F	DO47623	SKCM	ICGC	APAAAVSPM	DEG_SIAH_1	0.7068
p.S872I	TCGA-IB-7651	PAAD	TCGA	APAAAVSPM	DEG_SIAH_1	0.1389
p.S872I	DO46657	PAAD	ICGC	APAAAVSPM	DEG_SIAH_1	0.1389
p.S872N	TCGA-R5-A7ZI	STAD	TCGA	APAAAVSPM	DEG_SIAH_1	0.1389
p.S872N	DO222342	STAD	ICGC	APAAAVSPM	DEG_SIAH_1	0.1389
p.V862G	DO18164	KIRC	ICGC	APAAAVSPM	DEG_SIAH_1	0.7532
p.R875W	DO228916	LICA	ICGC	APAAAVSPM	DEG_SIAH_1	0.0556
p.R875W	SIDM01617	Endometrial Carcinoma	GDSC	APAAAVSPM	DEG_SIAH_1	0.0556
p.R875W	ACH-000994	Endometrial/Uterine Cancer	CCLE	APAAAVSPM	DEG_SIAH_1	0.0556
p.R875P	DO229459	SKCA	ICGC	APAAAVSPM	DEG_SIAH_1	0.0556
p.E867K	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	APAAAVSPM	DEG_SIAH_1	0.2778
p.A873V	SNU-175	large_intestine	COSMIC	APAAAVSPM	DEG_SIAH_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5M775	Cytospin-B	DEG_SIAH_1	857:865	APAAAVSPM	SIAH1,SIAH2,SIAH3	0.9954	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons