DegronMD - O43525(KCNQ3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G836C	TCGA-22-4595	LUSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1111
p.P735L	TCGA-28-1750	GBM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.6471
p.P735L	TCGA-FR-A3R1	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.6471
p.T740R	TCGA-43-A474	LUSC	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.25
p.L853V	TCGA-5L-AAT0	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.5654
p.R722Q	TCGA-A2-A0D4	BRCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.R722Q	TCGA-TS-A7P0	MESO	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.R722P	TCGA-A8-A079	BRCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.A834T	TCGA-AA-3855	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0556
p.A834T	TCGA-D5-6928	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0556
p.T842M	TCGA-AA-3864	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.2778
p.T842M	TCGA-AA-3864	COAD	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T842M	TCGA-CR-7399	HNSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.2778
p.T842M	TCGA-CR-7399	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T842M	TCGA-VQ-A8P2	STAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.2778
p.T842M	TCGA-VQ-A8P2	STAD	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.A738T	TCGA-AA-3947	COAD	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.3056
p.A738T	SIDM01307	Colorectal Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.3056
p.D862G	TCGA-B5-A0JY	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.G857V	TCGA-BF-A1PZ	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1389
p.G857V	TCGA-BF-A1PZ	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.G857V	TCGA-D3-A2J8	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1389
p.G857V	TCGA-D3-A2J8	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.G849C	TCGA-CC-A7IH	LIHC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.6489
p.G849S	TCGA-CG-4305	STAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.5882
p.T846M	TCGA-CV-7413	HNSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.7423
p.G724E	TCGA-D3-A1Q6	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.P734T	TCGA-DA-A1I5	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7031
p.T866A	TCGA-E2-A153	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T866A	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T866A	ACH-002275	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T866A	MN-60	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.G857E	TCGA-EB-A41A	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1389
p.G857E	TCGA-EB-A41A	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.3056
p.P844H	TCGA-EE-A2MQ	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.7694
p.E835K	TCGA-EO-A22U	UCEC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0833
p.E835K	TCGA-W3-AA1Q	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0833
p.G724R	TCGA-FS-A1ZZ	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.G724R	TCGA-YD-A89C	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.V730F	TCGA-GD-A6C6	BLCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7068
p.S863L	TCGA-GN-A266	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.S863L	ACH-000198	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.E835D	TCGA-HE-7130	KIRP	TCGA	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.0833
p.T746A	DO1574	BRCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation blocking phosphorylation signal	0.5278
p.T746A	MN-60	haematopoietic and lymphoid tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation blocking phosphorylation signal	0.5278
p.L733V	DO219593	BRCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.6765
p.T722M	DO8490	COAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.T722M	DO15759	HNSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.T722M	DO51761	STAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.G729C	DO50447	ESAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.3056
p.G729C	DO52181	LIHC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.3056
p.T726M	DO234162	ESAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.2222
p.T726M	DO233752	GACA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.2222
p.T726M	DO15567	HNSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.2222
p.P747T	DO228905	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.0556
p.P747T	LS-411N	large intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.0556
p.T746N	DO228948	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation blocking phosphorylation signal	0.5278
p.T746N	CAL-39	vulva	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation blocking phosphorylation signal	0.5278
p.P732T	DO229025	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7031
p.D742N	DO50938	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1944
p.P724T	DO231169	LUSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.G737E	DO50703	ORCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7199
p.G737E	DO37429	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7199
p.P724H	DO37810	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.G737V	DO37778	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7532
p.G737V	DO50279	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7532
p.S743L	DO37432	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1667
p.G729S	DO38823	STAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.3056
p.D742G	DO43041	UCEC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1944
p.T866N	SIDM00935	Other Solid Cancers	GDSC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T866N	ACH-002091	Skin Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.T866N	CAL-39	vulva	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.0556
p.G723E	SIDM00845	Burkitt's Lymphoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1389
p.G723E	SIDM00690	Head and Neck Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1389
p.G723E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1389
p.G723E	SIDM01133	Other Solid Cancers	GDSC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1389
p.T856S	SIDM00293	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6005
p.T856S	ACH-002052	Lung Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6005
p.T856S	LU-139	lung	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6005
p.P852S	SIDM00217	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6752
p.P852S	ACH-000999	Colon/Colorectal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6752
p.P852S	SNU-1040	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6752
p.T838M	SIDM00980	Gastric Carcinoma	GDSC	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1667
p.T838M	ACH-000948	Gastric Cancer	CCLE	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1667
p.T838M	ACH-001807	Liposarcoma	CCLE	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1667
p.T838M	23132-87	stomach	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.1667
p.P737A	RL	haematopoietic and lymphoid tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7503
p.T736S	LU-139	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7116
p.P732S	SNU-1040	large intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.6752
p.T854N	CAL-39	vulva	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7055
p.T745N	CAL-39	vulva	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.P840S	SNU-1040	large intestine	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation rewiring degron network	0.2222
p.T844S	LU-139	lung	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	844:850	Mutation altering degron motif	0.7116
p.P855T	LS-411N	large intestine	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7031
p.R745L	NCI-H526	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.P746T	LS-411N	large intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation blocking phosphorylation signal	0.5278
p.T854A	MN-60	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.7139
p.T745A	MN-60	haematopoietic and lymphoid tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation rewiring degron network	0.1111
p.P731S	SNU-1040	large intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.6752
p.T735S	LU-139	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	730:737	Mutation altering degron motif	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNQ3

UniProt ID: O43525

Entrez ID: 3786

Protein name: Potassium voltage-gated channel subfamily KQT member 3 (KQT-like 3) (Potassium channel subunit alpha KvLQT3) (Voltage-gated potassium channel subunit Kv7.3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNQ3 in