DegronMD

Uniprot ID: O43525

Source protein: Potassium voltage-gated channel subfamily KQT member 3

Source gene: KCNQ3

Class: DEG_SCF_FBW7_1

Location: 844:850

E3 ligase: FBXW7

DEGRON score: 0.9044

ASA_SCORE: 58.8857

COIL: 0.8721

CONS_SCORE: 0.3859

DSS_SCORE: 0.7184

HELIX: 0.0386

FCONS_SCORE: 1.0284

RIG_SCORE: 0.6582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G836C	TCGA-22-4595	LUSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.1111
p.A834T	TCGA-AA-3855	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.0556
p.A834T	TCGA-D5-6928	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.0556
p.T842M	TCGA-AA-3864	COAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.2778
p.T842M	TCGA-CR-7399	HNSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.2778
p.T842M	TCGA-VQ-A8P2	STAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.2778
p.G857V	TCGA-BF-A1PZ	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.1389
p.G857V	TCGA-D3-A2J8	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.1389
p.G849C	TCGA-CC-A7IH	LIHC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.6489
p.G849S	TCGA-CG-4305	STAD	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.5882
p.T846M	TCGA-CV-7413	HNSC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.7423
p.G857E	TCGA-EB-A41A	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.1389
p.P844H	TCGA-EE-A2MQ	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.7694
p.E835K	TCGA-EO-A22U	UCEC	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.0833
p.E835K	TCGA-W3-AA1Q	SKCM	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.0833
p.E835D	TCGA-HE-7130	KIRP	TCGA	PFTPSGS	DEG_SCF_FBW7_1	0.0833
p.T838M	SIDM00980	Gastric Carcinoma	GDSC	PFTPSGS	DEG_SCF_FBW7_1	0.1667
p.T838M	ACH-000948	Gastric Cancer	CCLE	PFTPSGS	DEG_SCF_FBW7_1	0.1667
p.T838M	ACH-001807	Liposarcoma	CCLE	PFTPSGS	DEG_SCF_FBW7_1	0.1667
p.T838M	23132-87	stomach	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	0.1667
p.P840S	SNU-1040	large_intestine	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	0.2222
p.T844S	LU-139	lung	COSMIC	PFTPSGS	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SCF_FBW7_1	844:850	PFTPSGS	FBXW7	0.9044	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons