DegronMD

Uniprot ID: O43525

Source protein: Potassium voltage-gated channel subfamily KQT member 3

Source gene: KCNQ3

Class: DEG_SCF_FBW7_1

Location: 730:737

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 76.7

COIL: 0.9134

CONS_SCORE: 0.338

DSS_SCORE: 0.6105

HELIX: 0.0206

FCONS_SCORE: 1.0592

RIG_SCORE: 0.6339

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P735L	TCGA-28-1750	GBM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.6471
p.P735L	TCGA-FR-A3R1	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.6471
p.T740R	TCGA-43-A474	LUSC	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.25
p.R722Q	TCGA-A2-A0D4	BRCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.R722Q	TCGA-TS-A7P0	MESO	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.R722P	TCGA-A8-A079	BRCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.A738T	TCGA-AA-3947	COAD	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.3056
p.A738T	SIDM01307	Colorectal Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	0.3056
p.G724E	TCGA-D3-A1Q6	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.P734T	TCGA-DA-A1I5	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.7031
p.G724R	TCGA-FS-A1ZZ	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.G724R	TCGA-YD-A89C	SKCM	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.V730F	TCGA-GD-A6C6	BLCA	TCGA	VQATPPSS	DEG_SCF_FBW7_1	0.7068
p.T746A	DO1574	BRCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.5278
p.T746A	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.5278
p.L733V	DO219593	BRCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.6765
p.T722M	DO8490	COAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.T722M	DO15759	HNSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.T722M	DO51761	STAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.G729C	DO50447	ESAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.3056
p.G729C	DO52181	LIHC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.3056
p.T726M	DO234162	ESAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.2222
p.T726M	DO233752	GACA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.2222
p.T726M	DO15567	HNSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.2222
p.P747T	DO228905	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.0556
p.P747T	LS-411N	large_intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.0556
p.T746N	DO228948	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.5278
p.T746N	CAL-39	vulva	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.5278
p.P732T	DO229025	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.7031
p.D742N	DO50938	LICA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1944
p.P724T	DO231169	LUSC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.G737E	DO50703	ORCA	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.7199
p.G737E	DO37429	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.7199
p.P724H	DO37810	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.G737V	DO37778	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.7532
p.G737V	DO50279	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.7532
p.S743L	DO37432	SKCM	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1667
p.G729S	DO38823	STAD	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.3056
p.D742G	DO43041	UCEC	ICGC	VQATPPSS	DEG_SCF_FBW7_1	0.1944
p.G723E	SIDM00845	Burkitt's Lymphoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	0.1389
p.G723E	SIDM00690	Head and Neck Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	0.1389
p.G723E	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VQATPPSS	DEG_SCF_FBW7_1	0.1389
p.G723E	SIDM01133	Other Solid Cancers	GDSC	VQATPPSS	DEG_SCF_FBW7_1	0.1389
p.P737A	RL	haematopoietic_and_lymphoid_tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.7503
p.T736S	LU-139	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.7116
p.P732S	SNU-1040	large_intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.6752
p.T745N	CAL-39	vulva	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.R745L	NCI-H526	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.P746T	LS-411N	large_intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.5278
p.T745A	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.1111
p.P731S	SNU-1040	large_intestine	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.6752
p.T735S	LU-139	lung	COSMIC	VQATPPSS	DEG_SCF_FBW7_1	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VQATPPSS

Degron related mutations and impact score

Drug responses associated with KCNQ3 mutations

All proteins holding degron of VQATPPSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SCF_FBW7_1	730:737	VQATPPSS	FBXW7	0.996	More...