DegronMD - O95487(SEC24B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A368S	TCGA-33-4566	LUSC	TCGA	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.3056
p.A368S	TCGA-33-4566	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.25
p.A368S	DO26790	LUSC	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.3056
p.A368S	DO26790	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.25
p.E381Q	TCGA-A8-A08R	BRCA	TCGA	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.E381Q	TCGA-A8-A08R	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.E381Q	TCGA-A8-A08R	BRCA	TCGA	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0833
p.E381Q	DO1255	BRCA	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.E381Q	DO1255	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.E381Q	DO1255	BRCA	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0833
p.S392N	TCGA-B7-A5TI	STAD	TCGA	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7069
p.S392N	DO222328	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7069
p.D385E	TCGA-CV-A6K1	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.D385E	TCGA-CV-A6K1	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1944
p.D385E	DO52078	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.0556
p.D385E	DO52078	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1944
p.S366G	TCGA-D9-A6EC	SKCM	TCGA	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.S366G	TCGA-D9-A6EC	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1944
p.S366G	DO50291	SKCM	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.S366G	DO50291	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1944
p.G377V	DO228948	LICA	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.G377V	DO228948	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2778
p.S367F	DO220882	MELA	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2778
p.S367F	DO220882	MELA	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.2222
p.A373D	DO35454	PACA	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation altering degron motif	0.7793
p.A373D	DO35454	PACA	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation altering degron motif	0.7793
p.P398L	DO229502	SKCA	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2222
p.D381Y	DO37444	SKCM	ICGC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1389
p.D381Y	DO37444	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.D381Y	DO37444	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0833
p.P396T	DO41831	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2778
p.V386M	SIDM00845	Burkitt's Lymphoma	GDSC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2222
p.V386M	ACH-001450	Lymphoma	CCLE	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.2222
p.R359T	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0556
p.R359T	ACH-000951	Lung Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0556
p.R359T	NCI-H2342	lung	COSMIC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.0556
p.N394D	SIDM00901	Endometrial Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.6932
p.N394D	ACH-000940	Endometrial/Uterine Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.6932
p.N394D	AN3-CA	endometrium	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.6932
p.N365H	ACH-000289	Brain Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.N365H	ACH-000289	Brain Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.N365H	ACH-002244	Head and Neck Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.N365H	ACH-002244	Head and Neck Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.N365H	HO-1-N-1	salivary gland	COSMIC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.2222
p.N365H	HO-1-N-1	salivary gland	COSMIC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1667
p.P401L	ACH-000809	Esophageal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1389
p.P401L	KYSE-410	oesophagus	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1389
p.P403T	A704	kidney	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.0833
p.P392A	KYSE-50	oesophagus	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7503
p.D393V	BEN	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation altering degron motif	0.7785
p.N363D	AN3-CA	endometrium	COSMIC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.1667
p.N363D	AN3-CA	endometrium	COSMIC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1111
p.P368T	A704	kidney	COSMIC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.3056
p.P368T	A704	kidney	COSMIC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.25
p.S402F	LS-123	large intestine	COSMIC	VDSSS	DEG_SPOP_SBC_1	390:394	Mutation rewiring degron network	0.1111
p.P366L	KYSE-410	oesophagus	COSMIC	PTPLSS	DEG_SCF_FBW7_1	369:374	Mutation rewiring degron network	0.25
p.P366L	KYSE-410	oesophagus	COSMIC	PLSST	DEG_SPOP_SBC_1	371:375	Mutation rewiring degron network	0.1944

Kaplan plot for SEC24B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC24B

UniProt ID: O95487

Entrez ID: 10427

Protein name: Protein transport protein Sec24B (SEC24-related protein B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC24B in