DegronMD

Uniprot ID: O95487

Source protein: Protein transport protein Sec24B

Source gene: SEC24B

Class: DEG_SCF_FBW7_1

Location: 369:374

E3 ligase: FBXW7

DEGRON score: 0.9895

ASA_SCORE: 77.2667

COIL: 0.9642

CONS_SCORE: 0.2887

DSS_SCORE: 0.8269

HELIX: 0.0213

FCONS_SCORE: 1.2181

RIG_SCORE: 0.5804

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A368S	TCGA-33-4566	LUSC	TCGA	PTPLSS	DEG_SCF_FBW7_1	0.3056
p.A368S	DO26790	LUSC	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.3056
p.E381Q	TCGA-A8-A08R	BRCA	TCGA	PTPLSS	DEG_SCF_FBW7_1	0.1389
p.E381Q	DO1255	BRCA	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.1389
p.S366G	TCGA-D9-A6EC	SKCM	TCGA	PTPLSS	DEG_SCF_FBW7_1	0.25
p.S366G	DO50291	SKCM	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.25
p.G377V	DO228948	LICA	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.25
p.S367F	DO220882	MELA	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.2778
p.A373D	DO35454	PACA	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.7793
p.D381Y	DO37444	SKCM	ICGC	PTPLSS	DEG_SCF_FBW7_1	0.1389
p.R359T	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PTPLSS	DEG_SCF_FBW7_1	0.0556
p.R359T	ACH-000951	Lung Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	0.0556
p.R359T	NCI-H2342	lung	COSMIC	PTPLSS	DEG_SCF_FBW7_1	0.0556
p.N365H	ACH-000289	Brain Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	0.2222
p.N365H	ACH-002244	Head and Neck Cancer	CCLE	PTPLSS	DEG_SCF_FBW7_1	0.2222
p.N365H	HO-1-N-1	salivary_gland	COSMIC	PTPLSS	DEG_SCF_FBW7_1	0.2222
p.N363D	AN3-CA	endometrium	COSMIC	PTPLSS	DEG_SCF_FBW7_1	0.1667
p.P368T	A704	kidney	COSMIC	PTPLSS	DEG_SCF_FBW7_1	0.3056
p.P366L	KYSE-410	oesophagus	COSMIC	PTPLSS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95487	Protein transport protein Sec24B	DEG_SCF_FBW7_1	369:374	PTPLSS	FBXW7	0.9895	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons