DegronMD

Uniprot ID: O95487

Source protein: Protein transport protein Sec24B

Source gene: SEC24B

Class: DEG_SPOP_SBC_1

Location: 390:394

E3 ligase: SPOP

DEGRON score: 0.9656

ASA_SCORE: 93.46

COIL: 0.948

CONS_SCORE: 0.2681

DSS_SCORE: 0.8557

HELIX: 0.0376

FCONS_SCORE: 1.064

RIG_SCORE: 0.5715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E381Q	TCGA-A8-A08R	BRCA	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0833
p.E381Q	DO1255	BRCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0833
p.S392N	TCGA-B7-A5TI	STAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7069
p.S392N	DO222328	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7069
p.D385E	TCGA-CV-A6K1	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1944
p.D385E	DO52078	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.P398L	DO229502	SKCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.D381Y	DO37444	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0833
p.P396T	DO41831	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2778
p.V386M	SIDM00845	Burkitt's Lymphoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.V386M	ACH-001450	Lymphoma	CCLE	VDSSS	DEG_SPOP_SBC_1	0.2222
p.N394D	SIDM00901	Endometrial Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.6932
p.N394D	ACH-000940	Endometrial/Uterine Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.6932
p.N394D	AN3-CA	endometrium	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.6932
p.P401L	ACH-000809	Esophageal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1389
p.P401L	KYSE-410	oesophagus	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.P403T	A704	kidney	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.0833
p.P392A	KYSE-50	oesophagus	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.7503
p.D393V	BEN	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.7785
p.S402F	LS-123	large_intestine	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons