DegronMD - Q52LW3(ARHGAP29)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.F535V	TCGA-34-5232	LUSC	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.5957
p.F535V	DO27168	LUSC	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.5957
p.E549K	TCGA-A5-A0G2	UCEC	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-D3-A5GS	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-EE-A2GT	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-ER-A19O	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-FI-A2D0	UCEC	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	TCGA-YG-AA3O	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO47706	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO37946	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO38063	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO51299	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO41235	UCEC	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	DO43891	UCEC	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.E549K	ACH-000904	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.0833
p.G1193V	TCGA-AA-3821	COAD	TCGA	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.6421
p.G1193V	DO9314	COAD	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.6421
p.F535L	TCGA-AG-3891	READ	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.587
p.F535L	DO36388	READ	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.587
p.N1179D	TCGA-AP-A051	UCEC	TCGA	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1667
p.N1179D	DO42673	UCEC	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1667
p.S171L	TCGA-AP-A0LM	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.5278
p.S171L	TCGA-BS-A0UF	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.5278
p.S171L	DO218884	SKCA	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.5278
p.S171L	DO43306	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.5278
p.S171L	DO41488	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.5278
p.S190F	TCGA-BF-AAP2	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	TCGA-DA-A1HV	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	TCGA-ER-A2NG	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO220881	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO222644	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO222749	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO37659	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO47552	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.S190F	DO219466	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation blocking phosphorylation signal	0.6111
p.G1200C	TCGA-BQ-7051	KIRP	TCGA	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1389
p.G1200C	DO20778	KIRP	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.1389
p.G546R	TCGA-CV-7568	HNSC	TCGA	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1667
p.G546R	DO14160	HNSC	ICGC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1667
p.G187E	TCGA-D3-A8GL	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.G187E	DO50287	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.25
p.P191L	TCGA-DA-A1IC	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.P191L	DO37430	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.D1195N	TCGA-DA-A95Z	SKCM	TCGA	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2778
p.D1195N	DO219481	SKCM	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2778
p.N188K	TCGA-EO-A22R	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2222
p.N188K	DO42713	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2222
p.S182L	TCGA-FD-A6TB	BLCA	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation altering degron motif	0.8778
p.S182L	DO51879	BLCA	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation altering degron motif	0.8778
p.E185K	TCGA-FW-A3R5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.E185K	DO37406	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.E178K	TCGA-GF-A6C9	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2778
p.E178K	DO51254	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.2778
p.E1181D	TCGA-GN-A26C	SKCM	TCGA	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2222
p.E1181D	DO37782	SKCM	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2222
p.E173K	TCGA-TN-A7HL	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.E173K	DO219080	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.P1183S	DO6695	CLLE	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.2778
p.A1189E	DO233240	GACA	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.659
p.F189L	DO52674	MALY	ICGC	VDSSS	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1944
p.A1189T	DO220880	MELA	ICGC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation altering degron motif	0.6028
p.D540N	SIDM00857	Melanoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.6932
p.D540N	ACH-000572	Skin Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.6932
p.D540N	G-361	skin	COSMIC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.6932
p.H1196Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.25
p.H1196Q	ACH-002302	Leukemia	CCLE	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.25
p.H1196Q	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.25
p.P527L	SIDM00797	Melanoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1111
p.P527L	ACH-000788	Skin Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1111
p.P527L	A2058	skin	COSMIC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1111
p.S539G	SIDM00683	Prostate Carcinoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.5882
p.S539G	ACH-000977	lymph node	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.5882
p.S539G	LNCaP-Clone-FGC	prostate	COSMIC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation altering degron motif	0.5882
p.V1202M	SIDM01045	Endometrial Carcinoma	GDSC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.0833
p.V1202M	EN	endometrium	COSMIC	SPSAAVPPG	DEG_SIAH_1	1185:1193	Mutation rewiring degron network	0.0833
p.G545R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1944
p.G545R	ACH-000904	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1944
p.G545R	ACH-001362	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1944
p.G545R	NCI-H1770	lung	COSMIC	FGMFSD	LIG_APCC_ABBA_1	535:540	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP29

UniProt ID: Q52LW3

Entrez ID: 9411

Protein name: Rho GTPase-activating protein 29 (PTPL1-associated RhoGAP protein 1) (Rho-type GTPase-activating protein 29)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP29 in