DegronMD

Uniprot ID: Q52LW3

Source protein: Rho GTPase-activating protein 29

Source gene: ARHGAP29

Class: DEG_SPOP_SBC_1

Location: 180:184

E3 ligase: SPOP

DEGRON score: 0.5545

ASA_SCORE: 75.28

COIL: 0.8568

CONS_SCORE: 0.2616

DSS_SCORE: 0.4126

HELIX: 0.115

FCONS_SCORE: 0.8777

RIG_SCORE: 0.6723

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S171L	TCGA-AP-A0LM	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.5278
p.S171L	TCGA-BS-A0UF	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.5278
p.S171L	DO218884	SKCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.5278
p.S171L	DO43306	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.5278
p.S171L	DO41488	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.5278
p.S190F	TCGA-BF-AAP2	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	TCGA-DA-A1HV	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	TCGA-ER-A2NG	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO220881	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO222644	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO222749	MELA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO37659	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO47552	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S190F	DO219466	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.G187E	TCGA-D3-A8GL	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.25
p.G187E	DO50287	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.25
p.P191L	TCGA-DA-A1IC	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.P191L	DO37430	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.N188K	TCGA-EO-A22R	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2222
p.N188K	DO42713	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.S182L	TCGA-FD-A6TB	BLCA	TCGA	VDSSS	DEG_SPOP_SBC_1	0.8778
p.S182L	DO51879	BLCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.8778
p.E185K	TCGA-FW-A3R5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.3056
p.E185K	DO37406	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.E178K	TCGA-GF-A6C9	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2778
p.E178K	DO51254	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2778
p.E173K	TCGA-TN-A7HL	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.E173K	DO219080	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.F189L	DO52674	MALY	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VDSSS

Degron related mutations and impact score

Drug responses associated with ARHGAP29 mutations

All proteins holding degron of VDSSS