DegronMD - Q6UX06(OLFM4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P32T	TCGA-17-Z015	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.P32T	DO234462	ESAD	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1111
p.S48T	TCGA-17-Z056	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2222
p.G33C	TCGA-BB-7870	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.G33C	DO14378	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.P30L	TCGA-FW-A3R5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.P30L	DO37406	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0556
p.S44A	TCGA-L9-A444	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.7588
p.S44A	DO26015	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.7588
p.S36F	TCGA-Z2-A8RT	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2222
p.S36F	DO51301	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.2222
p.S50F	DO229031	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation blocking phosphorylation signal	0.6111
p.S49C	DO231204	LUSC	ICGC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1944
p.F37L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.F37L	ACH-000186	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.F37L	NCI-H2444	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.25
p.D41Y	SIDM00924	Other Solid Cancers	GDSC	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.6214
p.D41Y	ACH-000867	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation altering degron motif	0.6214
p.R51M	ACH-000065	Leukemia	CCLE	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.1389
p.S31R	ACH-000598	Myeloma	CCLE	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.0833
p.S45N	ACH-000950	Colon/Colorectal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	40:44	Mutation rewiring degron network	0.3056

Kaplan plot for OLFM4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OLFM4

UniProt ID: Q6UX06

Entrez ID: 10562

Protein name: Olfactomedin-4 (OLM4) (Antiapoptotic protein GW112) (G-CSF-stimulated clone 1 protein) (hGC-1) (hOLfD)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OLFM4 in