DegronMD

Uniprot ID: Q6UX06

Source protein: Olfactomedin-4

Source gene: OLFM4

Class: DEG_SPOP_SBC_1

Location: 40:44

E3 ligase: SPOP

DEGRON score: 0.7065

ASA_SCORE: 61.4

COIL: 0.8338

CONS_SCORE: 0.2519

DSS_SCORE: 0.4346

HELIX: 0.0756

FCONS_SCORE: 1.0545

RIG_SCORE: 0.602

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S44A	TCGA-L9-A444	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7588
p.S44A	DO26015	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7588
p.D41Y	SIDM00924	Other Solid Cancers	GDSC	VDSSS	DEG_SPOP_SBC_1	0.6214
p.D41Y	ACH-000867	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.6214
p.S50F	DO229031	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6111
p.S45N	ACH-000950	Colon/Colorectal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.3056
p.F37L	SIDM00723	Non-Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.25
p.F37L	ACH-000186	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.25
p.F37L	NCI-H2444	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.25
p.S48T	TCGA-17-Z056	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2222
p.S36F	TCGA-Z2-A8RT	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2222
p.S36F	DO51301	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.S49C	DO231204	LUSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.G33C	TCGA-BB-7870	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.G33C	DO14378	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.R51M	ACH-000065	Leukemia	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1389
p.P32T	TCGA-17-Z015	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1111
p.P32T	DO234462	ESAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.S31R	ACH-000598	Myeloma	CCLE	VDSSS	DEG_SPOP_SBC_1	0.0833
p.P30L	TCGA-FW-A3R5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0556
p.P30L	DO37406	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...

Showing 1 to 16 of 16 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons