DegronMD - Q9H4S2(GSX1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S146N	TCGA-C5-A1M5	CESC	TCGA	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1944
p.S146N	DO6250	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1944
p.S146N	DO50970	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1944
p.P145L	TCGA-D1-A2G0	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.P145L	DO43049	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.H133Y	TCGA-DK-A3WW	BLCA	TCGA	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.H133Y	DO481	BLCA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.2222
p.R151C	TCGA-EA-A410	CESC	TCGA	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.R151C	DO49929	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.R151C	DO233089	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.R151C	DO233898	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.S139N	DO222884	COCA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation altering degron motif	0.7069
p.R151H	DO46673	PACA	ICGC	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.0556
p.F132L	ACH-000982	Colon/Colorectal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	137:141	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons