DegronMD

Uniprot ID: Q9H4S2

Source protein: GS homeobox 1

Source gene: GSX1

Class: DEG_SPOP_SBC_1

Location: 137:141

E3 ligase: SPOP

DEGRON score: 0.9033

ASA_SCORE: 70.44

COIL: 0.862

CONS_SCORE: 0.3506

DSS_SCORE: 0.4623

HELIX: 0.068

FCONS_SCORE: 0.6519

RIG_SCORE: 0.6595

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S146N	TCGA-C5-A1M5	CESC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1944
p.S146N	DO6250	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.S146N	DO50970	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.P145L	TCGA-D1-A2G0	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2222
p.P145L	DO43049	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.H133Y	TCGA-DK-A3WW	BLCA	TCGA	VDSSS	DEG_SPOP_SBC_1	0.2222
p.H133Y	DO481	BLCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.2222
p.R151C	TCGA-EA-A410	CESC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0556
p.R151C	DO49929	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.R151C	DO233089	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.R151C	DO233898	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.S139N	DO222884	COCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7069
p.R151H	DO46673	PACA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.F132L	ACH-000982	Colon/Colorectal Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons