DegronMD

Uniprot ID: Q8N612

Source protein: FHF complex subunit HOOK interacting protein 1B

Source gene: FHIP1B

Class: DEG_SPOP_SBC_1

Location: 485:489

E3 ligase: SPOP

DEGRON score: 0.9815

ASA_SCORE: 74.58

COIL: 0.9092

CONS_SCORE: 0.3408

DSS_SCORE: 0.6498

HELIX: 0.0658

FCONS_SCORE: 0.9392

RIG_SCORE: 0.5666

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P494L	TCGA-AP-A1DK	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1944
p.P494L	DO42033	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.G486E	TCGA-BR-6852	STAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7199
p.G486E	DO38202	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7199
p.R487K	TCGA-CA-6717	COAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7237
p.R487K	DO8264	COAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7237
p.R488K	TCGA-CR-7388	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7237
p.R488K	DO14284	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7237
p.P497Q	DO228985	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.T485K	DO229035	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7306
p.V499A	DO232858	NACA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.T485A	SIDM00845	Burkitt's Lymphoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.7139
p.T485A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	0.7139
p.T485A	SIDM01519	Head and Neck Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.7139
p.T485A	ACH-000786	Lymphoma	CCLE	VDSSS	DEG_SPOP_SBC_1	0.7139
p.P483A	ACH-000635	Ovarian Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.2778
p.A477S	ACH-001793	Liposarcoma	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R495Q	H2731	pleura	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons