DegronMD - Q8N612(FHIP1B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D864Y	TCGA-22-1005	LUSC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7325
p.D864Y	DO26632	LUSC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7325
p.D864Y	DO229211	THCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7325
p.A81T	TCGA-AD-6895	COAD	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.3056
p.A81T	DO8938	COAD	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.3056
p.G94R	TCGA-AP-A051	UCEC	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.1944
p.G94R	DO42673	UCEC	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.1944
p.P494L	TCGA-AP-A1DK	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.P494L	DO42033	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1944
p.A856V	TCGA-AR-A250	BRCA	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.6936
p.A856V	DO1802	BRCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.6936
p.R870Q	TCGA-AX-A0J1	UCEC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1667
p.R870Q	DO41199	UCEC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1667
p.G486E	TCGA-BR-6852	STAD	TCGA	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7199
p.G486E	DO38202	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7199
p.R487K	TCGA-CA-6717	COAD	TCGA	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7237
p.R487K	DO8264	COAD	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7237
p.S873F	TCGA-CJ-4903	KIRC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0833
p.S873F	DO18819	KIRC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0833
p.R488K	TCGA-CR-7388	HNSC	TCGA	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7237
p.R488K	DO14284	HNSC	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7237
p.R550Q	TCGA-DK-A3IN	BLCA	TCGA	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.R550Q	DO455	BLCA	ICGC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1389
p.R861H	TCGA-EO-A22R	UCEC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.8244
p.R861H	DO42713	UCEC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.8244
p.H72Q	TCGA-ER-A19Q	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.0556
p.H72Q	DO47497	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.0556
p.P90L	TCGA-FW-A3R5	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.3056
p.P90L	DO37406	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.3056
p.K847R	TCGA-GN-A265	SKCM	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0833
p.K847R	DO37491	SKCM	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0833
p.T73I	TCGA-IB-7651	PAAD	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.0833
p.T73I	DO46657	PAAD	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.0833
p.P87L	TCGA-YD-A9TA	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.7582
p.P87L	DO219503	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.7582
p.P854S	DO230312	COCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2778
p.P90T	DO222503	COCA	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.3056
p.S863Y	DO228976	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.712
p.S863Y	DO229042	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.712
p.P497Q	DO228985	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1111
p.P858T	DO229029	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.5919
p.T485K	DO229035	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7306
p.P548T	DO229041	LICA	ICGC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1944
p.P872Q	DO229045	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1111
p.T78I	DO48738	LIRI	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation rewiring degron network	0.2222
p.P87S	DO220861	MELA	ICGC	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.6752
p.V499A	DO232858	NACA	ICGC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.0556
p.S543F	DO49161	PACA	ICGC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation altering degron motif	0.7982
p.A545T	DO228138	PBCA	ICGC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.2778
p.R861C	DO229211	THCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.8301
p.R551W	SIDM00428	Acute Myeloid Leukemia	GDSC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1111
p.R551W	NB-4	haematopoietic and lymphoid tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1111
p.K868R	SIDM00845	Burkitt's Lymphoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.K868R	SIDM01519	Head and Neck Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.2222
p.T485A	SIDM00845	Burkitt's Lymphoma	GDSC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7139
p.T485A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7139
p.T485A	SIDM01519	Head and Neck Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7139
p.T485A	ACH-000786	Lymphoma	CCLE	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation altering degron motif	0.7139
p.V867G	SIDM00530	Esophageal Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.V867G	SIDM00591	Oral Cavity Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.V867G	KYAE-1	oesophagus	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.V867G	HO-1-u-1	upper aerodigestive tract	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.R870W	SIDM01181	Hepatocellular Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1667
p.R870W	SNU-398	liver	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.1667
p.R861G	SIDM00619	Thyroid Gland Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7568
p.R861G	ACH-002397	Thyroid Cancer	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7568
p.R861G	KMH-2	thyroid	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7568
p.G532C	SIDM01118	Small Cell Lung Carcinoma	GDSC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1667
p.G532C	ACH-002175	Lung Cancer	CCLE	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1667
p.G532C	NCI-H740	lung	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1667
p.R551Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1111
p.R551Q	ACH-000938	Leukemia	CCLE	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1111
p.R551Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.1111
p.R84H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.7133
p.R84H	ACH-000874	Leukemia	CCLE	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.7133
p.R84H	RS4-11	haematopoietic and lymphoid tissue	COSMIC	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.7133
p.R856W	ACH-000221	Liver Cancer	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7523
p.R856W	SNU-398	liver	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation altering degron motif	0.7523
p.P483A	ACH-000635	Ovarian Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.2778
p.S529F	ACH-000833	Sarcoma	CCLE	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.0833
p.P865T	ACH-001302	Neuroblastoma	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.3056
p.A477S	ACH-001793	Liposarcoma	CCLE	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1111
p.V86A	ACH-002275	Leukemia	CCLE	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.6936
p.V86A	MN-60	haematopoietic and lymphoid tissue	COSMIC	EDRAVPSA	DEG_COP1_1	82:89	Mutation altering degron motif	0.6936
p.R537Q	NALM-6	haematopoietic and lymphoid tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.3056
p.R537W	NB-4	haematopoietic and lymphoid tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.3056
p.R495Q	H2731	pleura	COSMIC	VDSSS	DEG_SPOP_SBC_1	485:489	Mutation rewiring degron network	0.1667
p.P544H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	538:543	Mutation rewiring degron network	0.3056
p.V853G	HO-1-u-1	upper aerodigestive tract	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.V853G	KYAE-1	oesophagus	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.25
p.R847G	KMH-2	thyroid	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	856:864	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FHIP1B

UniProt ID: Q8N612

Entrez ID: 84067

Protein name: FHF complex subunit HOOK interacting protein 1B (FHIP1B) (FTS and Hook-interacting protein) (FHIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FHIP1B in