DegronMD

Uniprot ID: Q8N612

Source protein: FHF complex subunit HOOK interacting protein 1B

Source gene: FHIP1B

Class: DEG_COP1_1

Location: 82:89

E3 ligase: COP1

DEGRON score: 0.8181

ASA_SCORE: 80.475

COIL: 0.718

CONS_SCORE: 0.3282

DSS_SCORE: 0.4578

HELIX: 0.2569

FCONS_SCORE: 0.9096

RIG_SCORE: 0.7217

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A81T	TCGA-AD-6895	COAD	TCGA	EDRAVPSA	DEG_COP1_1	0.3056
p.A81T	DO8938	COAD	ICGC	EDRAVPSA	DEG_COP1_1	0.3056
p.G94R	TCGA-AP-A051	UCEC	TCGA	EDRAVPSA	DEG_COP1_1	0.1944
p.G94R	DO42673	UCEC	ICGC	EDRAVPSA	DEG_COP1_1	0.1944
p.H72Q	TCGA-ER-A19Q	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	0.0556
p.H72Q	DO47497	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	0.0556
p.P90L	TCGA-FW-A3R5	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	0.3056
p.P90L	DO37406	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	0.3056
p.T73I	TCGA-IB-7651	PAAD	TCGA	EDRAVPSA	DEG_COP1_1	0.0833
p.T73I	DO46657	PAAD	ICGC	EDRAVPSA	DEG_COP1_1	0.0833
p.P87L	TCGA-YD-A9TA	SKCM	TCGA	EDRAVPSA	DEG_COP1_1	0.7582
p.P87L	DO219503	SKCM	ICGC	EDRAVPSA	DEG_COP1_1	0.7582
p.P90T	DO222503	COCA	ICGC	EDRAVPSA	DEG_COP1_1	0.3056
p.T78I	DO48738	LIRI	ICGC	EDRAVPSA	DEG_COP1_1	0.2222
p.P87S	DO220861	MELA	ICGC	EDRAVPSA	DEG_COP1_1	0.6752
p.R84H	SIDM01086	B-Lymphoblastic Leukemia	GDSC	EDRAVPSA	DEG_COP1_1	0.7133
p.R84H	ACH-000874	Leukemia	CCLE	EDRAVPSA	DEG_COP1_1	0.7133
p.R84H	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	EDRAVPSA	DEG_COP1_1	0.7133
p.V86A	ACH-002275	Leukemia	CCLE	EDRAVPSA	DEG_COP1_1	0.6936
p.V86A	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	EDRAVPSA	DEG_COP1_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_COP1_1	82:89	EDRAVPSA	COP1	0.8181	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons