DegronMD

Uniprot ID: Q8N612

Source protein: FHF complex subunit HOOK interacting protein 1B

Source gene: FHIP1B

Class: DEG_APCC_DBOX_1

Location: 856:864

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8604

ASA_SCORE: 79.1111

COIL: 0.4974

CONS_SCORE: 0.3592

DSS_SCORE: 0.5484

HELIX: 0.4896

FCONS_SCORE: 0.8964

RIG_SCORE: 0.6607

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D864Y	TCGA-22-1005	LUSC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.7325
p.D864Y	DO26632	LUSC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.7325
p.D864Y	DO229211	THCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.7325
p.A856V	TCGA-AR-A250	BRCA	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.6936
p.A856V	DO1802	BRCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.6936
p.R870Q	TCGA-AX-A0J1	UCEC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.1667
p.R870Q	DO41199	UCEC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.1667
p.S873F	TCGA-CJ-4903	KIRC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.0833
p.S873F	DO18819	KIRC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.0833
p.R861H	TCGA-EO-A22R	UCEC	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.8244
p.R861H	DO42713	UCEC	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.8244
p.K847R	TCGA-GN-A265	SKCM	TCGA	RRPSLGELL	DEG_APCC_DBOX_1	0.0833
p.K847R	DO37491	SKCM	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.0833
p.P854S	DO230312	COCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.2778
p.S863Y	DO228976	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.712
p.S863Y	DO229042	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.712
p.P858T	DO229029	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.5919
p.P872Q	DO229045	LICA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.1111
p.R861C	DO229211	THCA	ICGC	RRPSLGELL	DEG_APCC_DBOX_1	0.8301
p.K868R	SIDM00845	Burkitt's Lymphoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.2222
p.K868R	SIDM01519	Head and Neck Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.2222
p.V867G	SIDM00530	Esophageal Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.V867G	SIDM00591	Oral Cavity Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.V867G	KYAE-1	oesophagus	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.V867G	HO-1-u-1	upper_aerodigestive_tract	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.R870W	SIDM01181	Hepatocellular Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.1667
p.R870W	SNU-398	liver	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.1667
p.R861G	SIDM00619	Thyroid Gland Carcinoma	GDSC	RRPSLGELL	DEG_APCC_DBOX_1	0.7568
p.R861G	ACH-002397	Thyroid Cancer	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	0.7568
p.R861G	KMH-2	thyroid	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.7568
p.R856W	ACH-000221	Liver Cancer	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	0.7523
p.R856W	SNU-398	liver	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.7523
p.P865T	ACH-001302	Neuroblastoma	CCLE	RRPSLGELL	DEG_APCC_DBOX_1	0.3056
p.V853G	HO-1-u-1	upper_aerodigestive_tract	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.V853G	KYAE-1	oesophagus	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.25
p.R847G	KMH-2	thyroid	COSMIC	RRPSLGELL	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRPSLGELL

Degron related mutations and impact score

Drug responses associated with FHIP1B mutations

All proteins holding degron of RRPSLGELL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_APCC_DBOX_1	856:864	RRPSLGELL	APC,CDC20,FZR1	0.8604	More...