DegronMD

Uniprot ID: Q8N612

Source protein: FHF complex subunit HOOK interacting protein 1B

Source gene: FHIP1B

Class: DEG_SCF_FBW7_2

Location: 538:543

E3 ligase: FBXW7

DEGRON score: 0.9019

ASA_SCORE: 76.7667

COIL: 0.9127

CONS_SCORE: 0.3171

DSS_SCORE: 0.7097

HELIX: 0.0217

FCONS_SCORE: 0.8382

RIG_SCORE: 0.572

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R550Q	TCGA-DK-A3IN	BLCA	TCGA	PTPAEE	DEG_SCF_FBW7_2	0.1389
p.R550Q	DO455	BLCA	ICGC	PTPAEE	DEG_SCF_FBW7_2	0.1389
p.P548T	DO229041	LICA	ICGC	PTPAEE	DEG_SCF_FBW7_2	0.1944
p.S543F	DO49161	PACA	ICGC	PTPAEE	DEG_SCF_FBW7_2	0.7982
p.A545T	DO228138	PBCA	ICGC	PTPAEE	DEG_SCF_FBW7_2	0.2778
p.R551W	SIDM00428	Acute Myeloid Leukemia	GDSC	PTPAEE	DEG_SCF_FBW7_2	0.1111
p.R551W	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.1111
p.G532C	SIDM01118	Small Cell Lung Carcinoma	GDSC	PTPAEE	DEG_SCF_FBW7_2	0.1667
p.G532C	ACH-002175	Lung Cancer	CCLE	PTPAEE	DEG_SCF_FBW7_2	0.1667
p.G532C	NCI-H740	lung	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.1667
p.R551Q	SIDM00429	B-Lymphoblastic Leukemia	GDSC	PTPAEE	DEG_SCF_FBW7_2	0.1111
p.R551Q	ACH-000938	Leukemia	CCLE	PTPAEE	DEG_SCF_FBW7_2	0.1111
p.R551Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.1111
p.S529F	ACH-000833	Sarcoma	CCLE	PTPAEE	DEG_SCF_FBW7_2	0.0833
p.R537Q	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.3056
p.R537W	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.3056
p.P544H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PTPAEE	DEG_SCF_FBW7_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SCF_FBW7_2	538:543	PTPAEE	FBXW7	0.9019	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons