DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: DEG_SPOP_SBC_1

Location: 139:143

E3 ligase: SPOP

DEGRON score: 0.9816

ASA_SCORE: 73.78

COIL: 0.834

CONS_SCORE: 0.2932

DSS_SCORE: 0.6336

HELIX: 0.1254

FCONS_SCORE: 1.0314

RIG_SCORE: 0.6773

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G146V	TCGA-55-5899	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.25
p.G146V	DO26042	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.25
p.V152L	TCGA-63-A5MJ	LUSC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0833
p.V152L	DO219149	LUSC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0833
p.S143Y	TCGA-AX-A1CE	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.712
p.S143Y	DO42280	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.712
p.H134Y	TCGA-B5-A11E	UCEC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1944
p.H134Y	DO41644	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.A149S	TCGA-OR-A5KB	ACC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1667
p.P153Q	TCGA-W5-AA34	CHOL	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0556
p.V152A	DO233913	GACA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0833
p.M144I	DO229037	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.R133K	SIDM01118	Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.1667
p.R133K	ACH-002175	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1667
p.R133K	NCI-H740	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1667
p.G146D	ACH-000930	Breast Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons