DegronMD

Uniprot ID: Q9NY59

Source protein: Sphingomyelin phosphodiesterase 3

Source gene: SMPD3

Class: DEG_SPOP_SBC_1

Location: 234:238

E3 ligase: SPOP

DEGRON score: 0.8987

ASA_SCORE: 74.66

COIL: 0.8948

CONS_SCORE: 0.2817

DSS_SCORE: 0.722

HELIX: 0.0442

FCONS_SCORE: 0.9885

RIG_SCORE: 0.5849

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G227R	TCGA-44-8120	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.G227R	DO45402	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.V245M	TCGA-CH-5769	PRAD	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.V245M	TCGA-YZ-A985	UVM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.1389
p.V245M	DO36245	PRAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1389
p.A224V	TCGA-DX-AB2E	SARC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.0556
p.A224V	DO220073	SARC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556
p.G231E	TCGA-EE-A2A5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.25
p.G231E	DO37941	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.25
p.P239Q	TCGA-EE-A3AA	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	0.3056
p.P239Q	DO37571	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.R246C	DO229572	PRAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R246C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R246C	ACH-001127	Leukemia	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R246C	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.E240V	SIDM01194	Hepatocellular Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.2778
p.E240V	ACH-000420	Liver Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.2778
p.E240V	SNU-449	liver	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.2778
p.P233S	SIDM00516	Melanoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.P233S	ACH-002166	Skin Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.3056
p.P233S	MZ7-mel	skin	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.R246H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R246H	ACH-000888	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.1111
p.R246H	NCI-H1793	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.P239L	ACH-001145	Ovarian Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons