DegronMD - Q9NY59(SMPD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G227R	TCGA-44-8120	LUAD	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.G227R	DO45402	LUAD	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.A182T	TCGA-55-8301	LUAD	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.A182T	TCGA-CG-4442	STAD	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.A182T	TCGA-FI-A2D5	UCEC	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.A182T	DO24682	LUAD	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.A182T	DO38380	STAD	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.A182T	DO41331	UCEC	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.R157I	TCGA-AA-A00N	COAD	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.R157I	DO9876	COAD	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0556
p.Q166H	TCGA-AP-A0LM	UCEC	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.3056
p.Q166H	DO43306	UCEC	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.3056
p.R164W	TCGA-CG-5721	STAD	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164W	DO38192	STAD	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.V245M	TCGA-CH-5769	PRAD	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.V245M	TCGA-YZ-A985	UVM	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.V245M	DO36245	PRAD	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1389
p.P174T	TCGA-DA-A1I5	SKCM	TCGA	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.2778
p.P174T	DO37447	SKCM	ICGC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.2778
p.A224V	TCGA-DX-AB2E	SARC	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.A224V	DO220073	SARC	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.0556
p.G287R	TCGA-EB-A4XL	SKCM	TCGA	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.3056
p.G287R	DO220886	MELA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.3056
p.G287R	DO47401	SKCM	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.3056
p.S298F	TCGA-EE-A29E	SKCM	TCGA	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.2222
p.S298F	DO37831	SKCM	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.2222
p.G231E	TCGA-EE-A2A5	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.G231E	DO37941	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.25
p.P239Q	TCGA-EE-A3AA	SKCM	TCGA	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.P239Q	DO37571	SKCM	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.S296L	DO222600	COCA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.2778
p.R246C	DO229572	PRAD	ICGC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246C	ACH-001127	Leukemia	CCLE	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246C	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.D286N	DO36556	READ	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.2778
p.N281H	DO227677	SKCA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.1389
p.R164Q	SIDM00216	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164Q	SIDM00217	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164Q	ACH-000989	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164Q	ACH-000999	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164Q	SNU-175	large intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R164Q	SNU-1040	large intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.25
p.R299W	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.1944
p.R299W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation rewiring degron network	0.1944
p.A162D	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1944
p.A162D	ACH-002062	Lymphoma	CCLE	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1944
p.A162D	SLVL	haematopoietic and lymphoid tissue	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1944
p.E240V	SIDM01194	Hepatocellular Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.E240V	ACH-000420	Liver Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.E240V	SNU-449	liver	COSMIC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.2778
p.P233S	SIDM00516	Melanoma	GDSC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.P233S	ACH-002166	Skin Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.P233S	MZ7-mel	skin	COSMIC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056
p.D172N	SIDM00516	Melanoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.6932
p.D172N	ACH-002166	Skin Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.6932
p.D172N	MZ7-mel	skin	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation altering degron motif	0.6932
p.R159C	SIDM01182	Bladder Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1111
p.R159C	UM-UC-3	urinary tract	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.1111
p.T279M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation blocking phosphorylation signal	0.5278
p.T279M	SIDM00613	Glioblastoma	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation blocking phosphorylation signal	0.5278
p.T279M	KALS-1	central nervous system	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation blocking phosphorylation signal	0.5278
p.T279M	TE-12	oesophagus	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	288:294	Mutation blocking phosphorylation signal	0.5278
p.A181T	SIDM00217	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0833
p.A181T	ACH-000999	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0833
p.A181T	SNU-1040	large intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	167:172	Mutation rewiring degron network	0.0833
p.R246H	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246H	ACH-000888	Lung Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.R246H	NCI-H1793	lung	COSMIC	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.1111
p.P239L	ACH-001145	Ovarian Cancer	CCLE	VDSSS	DEG_SPOP_SBC_1	234:238	Mutation rewiring degron network	0.3056

Kaplan plot for SMPD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMPD3

UniProt ID: Q9NY59

Entrez ID: 55512

Protein name: Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMPD3 in