DegronMD

Uniprot ID: Q9NY59

Source protein: Sphingomyelin phosphodiesterase 3

Source gene: SMPD3

Class: LIG_APCC_ABBA_1

Location: 167:172

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.842

ASA_SCORE: 65.1667

COIL: 0.511

CONS_SCORE: 0.4888

DSS_SCORE: 0.3965

HELIX: 0.0282

FCONS_SCORE: 1.0357

RIG_SCORE: 0.8355

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A182T	TCGA-55-8301	LUAD	TCGA	IKIYID	LIG_APCC_ABBA_1	0.0556
p.A182T	TCGA-CG-4442	STAD	TCGA	IKIYID	LIG_APCC_ABBA_1	0.0556
p.A182T	TCGA-FI-A2D5	UCEC	TCGA	IKIYID	LIG_APCC_ABBA_1	0.0556
p.A182T	DO24682	LUAD	ICGC	IKIYID	LIG_APCC_ABBA_1	0.0556
p.A182T	DO38380	STAD	ICGC	IKIYID	LIG_APCC_ABBA_1	0.0556
p.A182T	DO41331	UCEC	ICGC	IKIYID	LIG_APCC_ABBA_1	0.0556
p.R157I	TCGA-AA-A00N	COAD	TCGA	IKIYID	LIG_APCC_ABBA_1	0.0556
p.R157I	DO9876	COAD	ICGC	IKIYID	LIG_APCC_ABBA_1	0.0556
p.Q166H	TCGA-AP-A0LM	UCEC	TCGA	IKIYID	LIG_APCC_ABBA_1	0.3056
p.Q166H	DO43306	UCEC	ICGC	IKIYID	LIG_APCC_ABBA_1	0.3056
p.R164W	TCGA-CG-5721	STAD	TCGA	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164W	DO38192	STAD	ICGC	IKIYID	LIG_APCC_ABBA_1	0.25
p.P174T	TCGA-DA-A1I5	SKCM	TCGA	IKIYID	LIG_APCC_ABBA_1	0.2778
p.P174T	DO37447	SKCM	ICGC	IKIYID	LIG_APCC_ABBA_1	0.2778
p.R164Q	SIDM00216	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164Q	SIDM00217	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164Q	ACH-000989	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164Q	ACH-000999	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164Q	SNU-175	large_intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.25
p.R164Q	SNU-1040	large_intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.25
p.A162D	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.1944
p.A162D	ACH-002062	Lymphoma	CCLE	IKIYID	LIG_APCC_ABBA_1	0.1944
p.A162D	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.1944
p.D172N	SIDM00516	Melanoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.6932
p.D172N	ACH-002166	Skin Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	0.6932
p.D172N	MZ7-mel	skin	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.6932
p.R159C	SIDM01182	Bladder Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.1111
p.R159C	UM-UC-3	urinary_tract	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.1111
p.A181T	SIDM00217	Colorectal Carcinoma	GDSC	IKIYID	LIG_APCC_ABBA_1	0.0833
p.A181T	ACH-000999	Colon/Colorectal Cancer	CCLE	IKIYID	LIG_APCC_ABBA_1	0.0833
p.A181T	SNU-1040	large_intestine	COSMIC	IKIYID	LIG_APCC_ABBA_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IKIYID

Degron related mutations and impact score

Drug responses associated with SMPD3 mutations

All proteins holding degron of IKIYID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY59	Sphingomyelin phosphodiesterase 3	LIG_APCC_ABBA_1	167:172	IKIYID	APC,CDC20,FZR1	0.842	More...