DegronMD

Uniprot ID: Q9NY59

Source protein: Sphingomyelin phosphodiesterase 3

Source gene: SMPD3

Class: DEG_SCF_TRCP1_1

Location: 288:294

E3 ligase: BTRC

DEGRON score: 0.9989

ASA_SCORE: 71.3

COIL: 0.9291

CONS_SCORE: 0.3421

DSS_SCORE: 0.8557

HELIX: 0.044

FCONS_SCORE: 1.0437

RIG_SCORE: 0.5185

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G287R	TCGA-EB-A4XL	SKCM	TCGA	DSGSLGS	DEG_SCF_TRCP1_1	0.3056
p.G287R	DO220886	MELA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.3056
p.G287R	DO47401	SKCM	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.3056
p.S298F	TCGA-EE-A29E	SKCM	TCGA	DSGSLGS	DEG_SCF_TRCP1_1	0.2222
p.S298F	DO37831	SKCM	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.2222
p.S296L	DO222600	COCA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.2778
p.D286N	DO36556	READ	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.2778
p.N281H	DO227677	SKCA	ICGC	DSGSLGS	DEG_SCF_TRCP1_1	0.1389
p.R299W	SIDM01004	Chronic Myelogenous Leukemia	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	0.1944
p.R299W	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	0.1944
p.T279M	SIDM00023	Esophageal Squamous Cell Carcinoma	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	0.5278
p.T279M	SIDM00613	Glioblastoma	GDSC	DSGSLGS	DEG_SCF_TRCP1_1	0.5278
p.T279M	KALS-1	central_nervous_system	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	0.5278
p.T279M	TE-12	oesophagus	COSMIC	DSGSLGS	DEG_SCF_TRCP1_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SCF_TRCP1_1	288:294	DSGSLGS	BTRC	0.9989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons