DegronMD

Uniprot ID: Q5T011

Source protein: KICSTOR complex protein SZT2

Source gene: SZT2

Class: DEG_SPOP_SBC_1

Location: 2343:2347

E3 ligase: SPOP

DEGRON score: 0.9669

ASA_SCORE: 82.12

COIL: 0.8596

CONS_SCORE: 0.3339

DSS_SCORE: 0.3764

HELIX: 0.0718

FCONS_SCORE: 1.087

RIG_SCORE: 0.7679

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2345L	DO222769	COCA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.7582
p.G2347R	TCGA-B0-4827	KIRC	TCGA	VDSSS	DEG_SPOP_SBC_1	0.7568
p.P2345S	DO36451	READ	ICGC	VDSSS	DEG_SPOP_SBC_1	0.6752
p.A2342V	DO47767	STAD	ICGC	VDSSS	DEG_SPOP_SBC_1	0.3056
p.R2338C	MFE-319	endometrium	COSMIC	VDSSS	DEG_SPOP_SBC_1	0.1944
p.A2353S	DO229028	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1667
p.A2353V	DO43747	UCEC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1667
p.E2355K	DO6323	CESC	ICGC	VDSSS	DEG_SPOP_SBC_1	0.1111
p.G2357V	DO229037	LICA	ICGC	VDSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6DCA0	AMMECR1-like protein	DEG_SPOP_SBC_1	55:59	VDSSS	SPOP	0.9677	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	139:143	VDSSS	SPOP	0.9816	More...
Q16829	Dual specificity protein phosphatase 7	DEG_SPOP_SBC_1	190:194	VDSSS	SPOP	0.7455	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	603:607	VDSSS	SPOP	0.9971	More...
Q8N612	FHF complex subunit HOOK interacting protein 1B	DEG_SPOP_SBC_1	485:489	VDSSS	SPOP	0.9815	More...
Q9H4S2	GS homeobox 1	DEG_SPOP_SBC_1	137:141	VDSSS	SPOP	0.9033	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	2343:2347	VDSSS	SPOP	0.9669	More...
Q6UX06	Olfactomedin-4	DEG_SPOP_SBC_1	40:44	VDSSS	SPOP	0.7065	More...
O43933	Peroxisome biogenesis factor 1	DEG_SPOP_SBC_1	237:241	VDSSS	SPOP	0.8555	More...
Q8NA82	Probable E3 ubiquitin-protein ligase MARCHF10	DEG_SPOP_SBC_1	573:577	VDSSS	SPOP	0.9813	More...
Q5VWN6	Protein TASOR 2	DEG_SPOP_SBC_1	1206:1210	VDSSS	SPOP	0.999	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	390:394	VDSSS	SPOP	0.9656	More...
Q52LW3	Rho GTPase-activating protein 29	DEG_SPOP_SBC_1	180:184	VDSSS	SPOP	0.5545	More...
Q9Y6X4	Soluble lamin-associated protein of 75 kDa	DEG_SPOP_SBC_1	633:637	VDSSS	SPOP	0.9898	More...
Q9NY59	Sphingomyelin phosphodiesterase 3	DEG_SPOP_SBC_1	234:238	VDSSS	SPOP	0.8987	More...
O95873	Uncharacterized protein C6orf47	DEG_SPOP_SBC_1	32:36	VDSSS	SPOP	0.9921	More...

Showing 1 to 16 of 16 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons