DegronMD

Uniprot ID: Q52LW3

Source protein: Rho GTPase-activating protein 29

Source gene: ARHGAP29

Class: DEG_SIAH_1

Location: 1185:1193

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.992

ASA_SCORE: 72.5

COIL: 0.9059

CONS_SCORE: 0.2288

DSS_SCORE: 0.7711

HELIX: 0.0321

FCONS_SCORE: 1.0263

RIG_SCORE: 0.5464

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1193V	TCGA-AA-3821	COAD	TCGA	SPSAAVPPG	DEG_SIAH_1	0.6421
p.G1193V	DO9314	COAD	ICGC	SPSAAVPPG	DEG_SIAH_1	0.6421
p.N1179D	TCGA-AP-A051	UCEC	TCGA	SPSAAVPPG	DEG_SIAH_1	0.1667
p.N1179D	DO42673	UCEC	ICGC	SPSAAVPPG	DEG_SIAH_1	0.1667
p.G1200C	TCGA-BQ-7051	KIRP	TCGA	SPSAAVPPG	DEG_SIAH_1	0.1389
p.G1200C	DO20778	KIRP	ICGC	SPSAAVPPG	DEG_SIAH_1	0.1389
p.D1195N	TCGA-DA-A95Z	SKCM	TCGA	SPSAAVPPG	DEG_SIAH_1	0.2778
p.D1195N	DO219481	SKCM	ICGC	SPSAAVPPG	DEG_SIAH_1	0.2778
p.E1181D	TCGA-GN-A26C	SKCM	TCGA	SPSAAVPPG	DEG_SIAH_1	0.2222
p.E1181D	DO37782	SKCM	ICGC	SPSAAVPPG	DEG_SIAH_1	0.2222
p.P1183S	DO6695	CLLE	ICGC	SPSAAVPPG	DEG_SIAH_1	0.2778
p.A1189E	DO233240	GACA	ICGC	SPSAAVPPG	DEG_SIAH_1	0.659
p.A1189T	DO220880	MELA	ICGC	SPSAAVPPG	DEG_SIAH_1	0.6028
p.H1196Q	SIDM00482	Chronic Myelogenous Leukemia	GDSC	SPSAAVPPG	DEG_SIAH_1	0.25
p.H1196Q	ACH-002302	Leukemia	CCLE	SPSAAVPPG	DEG_SIAH_1	0.25
p.H1196Q	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	SPSAAVPPG	DEG_SIAH_1	0.25
p.V1202M	SIDM01045	Endometrial Carcinoma	GDSC	SPSAAVPPG	DEG_SIAH_1	0.0833
p.V1202M	EN	endometrium	COSMIC	SPSAAVPPG	DEG_SIAH_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q52LW3	Rho GTPase-activating protein 29	DEG_SIAH_1	1185:1193	SPSAAVPPG	SIAH1,SIAH2,SIAH3	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons