DegronMD

Uniprot ID: Q52LW3

Source protein: Rho GTPase-activating protein 29

Source gene: ARHGAP29

Class: LIG_APCC_ABBA_1

Location: 535:540

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.969

ASA_SCORE: 81.5167

COIL: 0.7828

CONS_SCORE: 0.2799

DSS_SCORE: 0.4575

HELIX: 0.0868

FCONS_SCORE: 0.9423

RIG_SCORE: 0.7397

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F535V	TCGA-34-5232	LUSC	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.5957
p.F535V	DO27168	LUSC	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.5957
p.E549K	TCGA-A5-A0G2	UCEC	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	TCGA-D3-A5GS	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	TCGA-EE-A2GT	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	TCGA-ER-A19O	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	TCGA-FI-A2D0	UCEC	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	TCGA-YG-AA3O	SKCM	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO47706	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO37946	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO38063	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO51299	SKCM	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO41235	UCEC	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	DO43891	UCEC	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.E549K	ACH-000904	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.0833
p.F535L	TCGA-AG-3891	READ	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.587
p.F535L	DO36388	READ	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.587
p.G546R	TCGA-CV-7568	HNSC	TCGA	FGMFSD	LIG_APCC_ABBA_1	0.1667
p.G546R	DO14160	HNSC	ICGC	FGMFSD	LIG_APCC_ABBA_1	0.1667
p.D540N	SIDM00857	Melanoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	0.6932
p.D540N	ACH-000572	Skin Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.6932
p.D540N	G-361	skin	COSMIC	FGMFSD	LIG_APCC_ABBA_1	0.6932
p.P527L	SIDM00797	Melanoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	0.1111
p.P527L	ACH-000788	Skin Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.1111
p.P527L	A2058	skin	COSMIC	FGMFSD	LIG_APCC_ABBA_1	0.1111
p.S539G	SIDM00683	Prostate Carcinoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	0.5882
p.S539G	ACH-000977	lymph_node	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.5882
p.S539G	LNCaP-Clone-FGC	prostate	COSMIC	FGMFSD	LIG_APCC_ABBA_1	0.5882
p.G545R	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	FGMFSD	LIG_APCC_ABBA_1	0.1944
p.G545R	ACH-000904	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.1944
p.G545R	ACH-001362	Lung Cancer	CCLE	FGMFSD	LIG_APCC_ABBA_1	0.1944
p.G545R	NCI-H1770	lung	COSMIC	FGMFSD	LIG_APCC_ABBA_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FGMFSD

Degron related mutations and impact score

Drug responses associated with ARHGAP29 mutations

All proteins holding degron of FGMFSD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q52LW3	Rho GTPase-activating protein 29	LIG_APCC_ABBA_1	535:540	FGMFSD	APC,CDC20,FZR1	0.969	More...