DegronMD - Q13873(BMPR2)

GO - Biological processes (BP): anterior/posterior pattern specification [GO:0009952]; aortic valve development [GO:0003176]; artery development [GO:0060840]; atrial septum morphogenesis [GO:0060413]; blood vessel development [GO:0001568]; blood vessel remodeling [GO:0001974]; BMP signaling pathway [GO:0030509]; cellular response to BMP stimulus [GO:0071773]; cellular response to growth factor stimulus [GO:0071363]; cellular response to starvation [GO:0009267]; chondrocyte development [GO:0002063]; endocardial cushion development [GO:0003197]; endochondral bone morphogenesis [GO:0060350]; endothelial cell apoptotic process [GO:0072577]; endothelial cell proliferation [GO:0001935]; limb development [GO:0060173]; lung alveolus development [GO:0048286]; lymphangiogenesis [GO:0001946]; lymphatic endothelial cell differentiation [GO:0060836]; maternal placenta development [GO:0001893]; mesoderm formation [GO:0001707]; mitral valve morphogenesis [GO:0003183]; negative regulation of cell growth [GO:0030308]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of chondrocyte proliferation [GO:1902731]; negative regulation of DNA biosynthetic process [GO:2000279]; negative regulation of muscle cell differentiation [GO:0051148]; negative regulation of smooth muscle cell proliferation [GO:0048662]; negative regulation of systemic arterial blood pressure [GO:0003085]; negative regulation of vasoconstriction [GO:0045906]; osteoblast differentiation [GO:0001649]; outflow tract morphogenesis [GO:0003151]; outflow tract septum morphogenesis [GO:0003148]; pharyngeal arch artery morphogenesis [GO:0061626]; positive regulation of axon extension involved in axon guidance [GO:0048842]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of bone mineralization [GO:0030501]; positive regulation of cartilage development [GO:0061036]; positive regulation of endothelial cell migration [GO:0010595]; positive regulation of endothelial cell proliferation [GO:0001938]; positive regulation of epithelial cell migration [GO:0010634]; positive regulation of ossification [GO:0045778]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862]; positive regulation of SMAD protein signal transduction [GO:0060391]; positive regulation of transcription by RNA polymerase II [GO:0045944]; protein phosphorylation [GO:0006468]; proteoglycan biosynthetic process [GO:0030166]; pulmonary valve development [GO:0003177]; regulation of cell population proliferation [GO:0042127]; regulation of lung blood pressure [GO:0014916]; retina vasculature development in camera-type eye [GO:0061298]; semi-lunar valve development [GO:1905314]; transmembrane receptor protein serine/threonine kinase signaling pathway [GO:0007178]; tricuspid valve morphogenesis [GO:0003186]; venous blood vessel development [GO:0060841]; ventricular septum morphogenesis [GO:0060412] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H688L	TCGA-94-A5I4	LUSC	TCGA	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.H688L	DO219175	LUSC	ICGC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.0556
p.R536H	TCGA-A6-5665	COAD	TCGA	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation rewiring degron network	0.2222
p.R536H	DO9756	COAD	ICGC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation rewiring degron network	0.2222
p.R536C	TCGA-AM-5821	COAD	TCGA	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation rewiring degron network	0.2222
p.R536C	DO8240	COAD	ICGC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation rewiring degron network	0.2222
p.R536C	DO228138	PBCA	ICGC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation rewiring degron network	0.2222
p.S547F	TCGA-BT-A20R	BLCA	TCGA	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation blocking phosphorylation signal	0.7222
p.S547F	DO622	BLCA	ICGC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation blocking phosphorylation signal	0.7222
p.S547F	SIDM00403	T-Lymphoblastic Leukemia	GDSC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation blocking phosphorylation signal	0.7222
p.S547F	ACH-000636	Leukemia	CCLE	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation blocking phosphorylation signal	0.7222
p.S547F	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	IGPYPD	LIG_APCC_ABBA_1	540:545	Mutation blocking phosphorylation signal	0.7222
p.D697Y	TCGA-EE-A20F	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.D697Y	DO37961	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.P698Q	TCGA-OL-A6VO	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7035
p.P698Q	DO51213	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation altering degron motif	0.7035
p.G695D	DO232761	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.25
p.D697N	SIDM00807	Bladder Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.D697N	ACH-000905	Bladder Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056
p.D697N	5637	urinary tract	COSMIC	PLSST	DEG_SPOP_SBC_1	698:702	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BMPR2

UniProt ID: Q13873

Entrez ID: 659

Protein name: Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BMPR2 in