DegronMD

Uniprot ID: Q13873

Source protein: Bone morphogenetic protein receptor type-2

Source gene: BMPR2

Class: LIG_APCC_ABBA_1

Location: 540:545

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9934

ASA_SCORE: 77.4333

COIL: 0.8528

CONS_SCORE: 0.3718

DSS_SCORE: 0.5077

HELIX: 0.0178

FCONS_SCORE: 0.9374

RIG_SCORE: 0.6587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R536H	TCGA-A6-5665	COAD	TCGA	IGPYPD	LIG_APCC_ABBA_1	0.2222
p.R536H	DO9756	COAD	ICGC	IGPYPD	LIG_APCC_ABBA_1	0.2222
p.R536C	TCGA-AM-5821	COAD	TCGA	IGPYPD	LIG_APCC_ABBA_1	0.2222
p.R536C	DO8240	COAD	ICGC	IGPYPD	LIG_APCC_ABBA_1	0.2222
p.R536C	DO228138	PBCA	ICGC	IGPYPD	LIG_APCC_ABBA_1	0.2222
p.S547F	TCGA-BT-A20R	BLCA	TCGA	IGPYPD	LIG_APCC_ABBA_1	0.7222
p.S547F	DO622	BLCA	ICGC	IGPYPD	LIG_APCC_ABBA_1	0.7222
p.S547F	SIDM00403	T-Lymphoblastic Leukemia	GDSC	IGPYPD	LIG_APCC_ABBA_1	0.7222
p.S547F	ACH-000636	Leukemia	CCLE	IGPYPD	LIG_APCC_ABBA_1	0.7222
p.S547F	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	IGPYPD	LIG_APCC_ABBA_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13873	Bone morphogenetic protein receptor type-2	LIG_APCC_ABBA_1	540:545	IGPYPD	APC,CDC20,FZR1	0.9934	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons