DegronMD

Uniprot ID: Q9Y2W1

Source protein: Thyroid hormone receptor-associated protein 3

Source gene: THRAP3

Class: DEG_SPOP_SBC_1

Location: 276:280

E3 ligase: SPOP

DEGRON score: 0.9859

ASA_SCORE: 90.56

COIL: 0.9328

CONS_SCORE: 0.5928

DSS_SCORE: 0.7619

HELIX: 0.0524

FCONS_SCORE: 0.9984

RIG_SCORE: 0.5524

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P267S	TCGA-3A-A9I9	PAAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.0833
p.P267S	DO51679	PAAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.0833
p.P267L	TCGA-3A-A9I9	PAAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.0833
p.P267L	DO51679	PAAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.0833
p.P267T	TCGA-62-8399	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	0.0833
p.P267T	DO24606	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.0833
p.G284S	TCGA-BG-A222	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	0.2222
p.G284S	DO42977	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.G290D	TCGA-BH-A0HF	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	0.0556
p.G290D	DO1749	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.R266C	TCGA-CV-7568	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	0.0556
p.R266C	DO14160	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	0.0556
p.P273H	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.25
p.P273H	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.25
p.Q282K	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.2778
p.Q282K	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.2778
p.S279N	TCGA-FW-A3R5	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	0.7069
p.S279N	DO37406	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	0.7069
p.L287V	TCGA-TM-A7CF	LGG	TCGA	PLSST	DEG_SPOP_SBC_1	0.1389
p.L287V	DO50229	LGG	ICGC	PLSST	DEG_SPOP_SBC_1	0.1389
p.V270M	DO234192	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	0.1667
p.G284V	DO229034	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	0.2222
p.P288L	DO23240	LINC	ICGC	PLSST	DEG_SPOP_SBC_1	0.1111
p.P288L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.1111
p.P288L	ACH-001738	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	0.1111
p.P276L	DO232532	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	0.7582
p.T286A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00656	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00087	Plasma Cell Myeloma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00846	Cervical Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01112	Osteosarcoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00878	Breast Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00793	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00785	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01318	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM00641	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01664	Prostate Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.T286A	SIDM01525	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.1667
p.R266H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	0.0556
p.R266H	ACH-002256	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	0.0556
p.R266H	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15550	Lysine-specific demethylase 6A	DEG_SPOP_SBC_1	659:663	PLSST	SPOP	0.9969	More...
O43525	Potassium voltage-gated channel subfamily KQT member 3	DEG_SPOP_SBC_1	852:856	PLSST	SPOP	0.9413	More...
O95487	Protein transport protein Sec24B	DEG_SPOP_SBC_1	371:375	PLSST	SPOP	0.9973	More...
P58107	Epiplakin	DEG_SPOP_SBC_1	797:801	PLSST	SPOP	0.7149	More...
Q13873	Bone morphogenetic protein receptor type-2	DEG_SPOP_SBC_1	698:702	PLSST	SPOP	0.9891	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	320:324	PLSST	SPOP	0.9988	More...
Q15714	TSC22 domain family protein 1	DEG_SPOP_SBC_1	891:895	PLSST	SPOP	0.9403	More...
Q49AJ0	Protein FAM135B	DEG_SPOP_SBC_1	643:647	PLSST	SPOP	0.9487	More...
Q5M775	Cytospin-B	DEG_SPOP_SBC_1	342:346	PLSST	SPOP	0.9835	More...
Q66GS9	Centrosomal protein of 135 kDa	DEG_SPOP_SBC_1	1123:1127	PLSST	SPOP	0.9913	More...
Q69YN4	Protein virilizer homolog	DEG_SPOP_SBC_1	1757:1761	PLSST	SPOP	0.9993	More...
Q6P4R8	Nuclear factor related to kappa-B-binding protein	DEG_SPOP_SBC_1	336:340	PLSST	SPOP	0.984	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1665:1669	PLSST	SPOP	0.9861	More...
Q8IW45	ATP-dependent	DEG_SPOP_SBC_1	63:67	PLSST	SPOP	0.9107	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1684:1688	PLSST	SPOP	0.9408	More...
Q92546	RAB6A-GEF complex partner protein 2	DEG_SPOP_SBC_1	306:310	PLSST	SPOP	0.6123	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	393:397	PLSST	SPOP	0.9714	More...
Q96PX1	E3 ubiquitin ligase RNF157	DEG_SPOP_SBC_1	499:503	PLSST	SPOP	0.976	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	71:75	PLSST	SPOP	0.9941	More...
Q9NR46	Endophilin-B2	DEG_SPOP_SBC_1	295:299	PLSST	SPOP	0.6401	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	1908:1912	PLSST	SPOP	0.9775	More...
Q9Y2W1	Thyroid hormone receptor-associated protein 3	DEG_SPOP_SBC_1	276:280	PLSST	SPOP	0.9859	More...
Q5VVH5	Interleukin-1 receptor-associated kinase 1-binding protein 1	DEG_SPOP_SBC_1	40:44	PLSST	SPOP	0.9797	More...
Q8WZ64	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	452:456	PLSST	SPOP	0.8986	More...
Q9Y5F7	Protocadherin gamma-C4	DEG_SPOP_SBC_1	544:548	PLSST	SPOP	0.8845	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSST

Degron related mutations and impact score

Drug responses associated with THRAP3 mutations

All proteins holding degron of PLSST