DegronMD - Q92546(RGP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S385N	TCGA-BS-A0UV	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.5958
p.S385N	DO42793	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.5958
p.L376P	TCGA-CA-6717	COAD	TCGA	PSTST	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111
p.L376P	DO8264	COAD	ICGC	PSTST	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1111
p.V145F	TCGA-CV-5432	HNSC	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1389
p.V145F	DO14343	HNSC	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1389
p.Y379N	TCGA-CZ-4853	KIRC	TCGA	PSTST	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.Y379N	DO16111	KIRC	ICGC	PSTST	DEG_SPOP_SBC_1	384:388	Mutation rewiring degron network	0.1944
p.L164F	TCGA-D3-A2JC	SKCM	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2222
p.L164F	DO47578	SKCM	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.2222
p.P170L	TCGA-D3-A8GI	SKCM	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0556
p.P170L	DO50284	SKCM	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0556
p.G163V	TCGA-DX-A6YT	SARC	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.25
p.G163V	DO220007	SARC	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.25
p.P306H	TCGA-FS-A1ZZ	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7694
p.P306H	DO37412	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7694
p.F169V	TCGA-G9-6338	PRAD	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.F169V	DO36375	PRAD	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0833
p.Q165H	TCGA-L9-A444	LUAD	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1944
p.Q165H	DO26015	LUAD	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.1944
p.G312S	DO228483	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	DO229010	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	DO229003	COCA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	DO229047	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00305	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00216	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00437	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00578	Neuroblastoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00450	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01151	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01040	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00781	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00362	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00465	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00296	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00589	Oral Cavity Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00293	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00238	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00619	Thyroid Gland Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01093	Cervical Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00235	Kidney Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01045	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00585	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00567	Other Solid Cancers	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01217	Other Blood Cancers	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00604	Oral Cavity Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00381	Cervical Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01033	Bladder Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00359	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01609	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01569	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01335	Kidney Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01498	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01368	Gastric Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01320	Pancreatic Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01444	Glioblastoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00008	Ovarian Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00780	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01454	Kidney Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01782	Oral Cavity Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM00171	Colorectal Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01753	Gastric Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01391	Neuroblastoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.G312S	SIDM01619	Endometrial Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.I305V	DO222821	BTCA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.3056
p.A316V	DO233212	GACA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1667
p.C142F	DO229027	LICA	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0556
p.C142F	DO45277	LIRI	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation rewiring degron network	0.0556
p.S308I	DO229027	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7341
p.A316S	DO232761	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1667
p.L159V	SIDM01006	Plasma Cell Myeloma	GDSC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.5654
p.L159V	KARPAS-620	haematopoietic and lymphoid tissue	COSMIC	LRVPLRVLV	DEG_APCC_DBOX_1	152:160	Mutation altering degron motif	0.5654
p.T388A	SIDM00643	Non-Cancerous	GDSC	PSTST	DEG_SPOP_SBC_1	384:388	Mutation altering degron motif	0.7139
p.T310N	SIDM00874	Breast Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7055
p.T310N	HCC1937	breast	COSMIC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7055
p.T310A	SIDM00363	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7139
p.T310A	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGP1

UniProt ID: Q92546

Entrez ID: 9827

Protein name: RAB6A-GEF complex partner protein 2 (Retrograde Golgi transport protein RGP1 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RGP1 in