DegronMD

Uniprot ID: Q92546

Source protein: RAB6A-GEF complex partner protein 2

Source gene: RGP1

Class: DEG_APCC_DBOX_1

Location: 152:160

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5682

ASA_SCORE: 44.5778

COIL: 0.2729

CONS_SCORE: 0.6195

DSS_SCORE: 0.0345

HELIX: 0.0287

FCONS_SCORE: 1.5427

RIG_SCORE: 0.953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V145F	TCGA-CV-5432	HNSC	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.1389
p.V145F	DO14343	HNSC	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.1389
p.L164F	TCGA-D3-A2JC	SKCM	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.2222
p.L164F	DO47578	SKCM	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.2222
p.P170L	TCGA-D3-A8GI	SKCM	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.0556
p.P170L	DO50284	SKCM	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.0556
p.G163V	TCGA-DX-A6YT	SARC	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.25
p.G163V	DO220007	SARC	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.25
p.F169V	TCGA-G9-6338	PRAD	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.0833
p.F169V	DO36375	PRAD	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.0833
p.Q165H	TCGA-L9-A444	LUAD	TCGA	LRVPLRVLV	DEG_APCC_DBOX_1	0.1944
p.Q165H	DO26015	LUAD	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.1944
p.C142F	DO229027	LICA	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.0556
p.C142F	DO45277	LIRI	ICGC	LRVPLRVLV	DEG_APCC_DBOX_1	0.0556
p.L159V	SIDM01006	Plasma Cell Myeloma	GDSC	LRVPLRVLV	DEG_APCC_DBOX_1	0.5654
p.L159V	KARPAS-620	haematopoietic_and_lymphoid_tissue	COSMIC	LRVPLRVLV	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92546	RAB6A-GEF complex partner protein 2	DEG_APCC_DBOX_1	152:160	LRVPLRVLV	APC,CDC20,FZR1	0.5682	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons