DegronMD - Q9Y2W1(THRAP3)

FUNCTION: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. M... View more >>

GO - Biological processes (BP): circadian rhythm [GO:0007623]; mRNA processing [GO:0006397]; mRNA stabilization [GO:0048255]; nuclear-transcribed mRNA catabolic process [GO:0000956]; positive regulation of circadian rhythm [GO:0042753]; positive regulation of mRNA splicing, via spliceosome [GO:0048026]; positive regulation of tran... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; DNA binding [GO:0003677]; nuclear receptor coactivator activity [GO:0030374]; phosphoprotein binding [GO:0051219]; RNA binding [GO:0003723]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; thyroid hormone receptor binding [GO:0046966]; tr... View more >>

GO - Cellular component (CC): extracellular exosome [GO:0070062]; mediator complex [GO:0016592]; nuclear speck [GO:0016607]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P276L	DO232532	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7582
p.Y880C	DO23238	LINC	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation altering degron motif	0.7087
p.S279N	TCGA-FW-A3R5	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7069
p.S279N	DO37406	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7069
p.Y873C	TCGA-VQ-A8P2	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation blocking phosphorylation signal	0.6111
p.Y873C	DO51761	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation blocking phosphorylation signal	0.6111
p.R886C	TCGA-CG-5733	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R886C	DO38551	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R886H	TCGA-GV-A3QI	BLCA	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R886H	DO470	BLCA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.Q282K	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.Q282K	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.P273H	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.P273H	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.G284S	TCGA-BG-A222	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.G284S	DO42977	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.P875T	TCGA-IN-A6RO	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.2222
p.P875T	DO51740	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.2222
p.G284V	DO229034	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.G890C	DO233624	GACA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 57 entries

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Kaplan plot for THRAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THRAP3

UniProt ID: Q9Y2W1

Entrez ID: 9967

Protein name: Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THRAP3 in