DegronMD - Q9Y2W1(THRAP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P267S	TCGA-3A-A9I9	PAAD	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P267S	DO51679	PAAD	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P267L	TCGA-3A-A9I9	PAAD	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P267L	DO51679	PAAD	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P267T	TCGA-62-8399	LUAD	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.P267T	DO24606	LUAD	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0833
p.G284S	TCGA-BG-A222	UCEC	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.G284S	DO42977	UCEC	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.G290D	TCGA-BH-A0HF	BRCA	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.G290D	DO1749	BRCA	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.R886C	TCGA-CG-5733	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R886C	DO38551	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R266C	TCGA-CV-7568	HNSC	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.R266C	DO14160	HNSC	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.P273H	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.P273H	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.25
p.Q282K	TCGA-D3-A2JP	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.Q282K	DO47407	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2778
p.S279N	TCGA-FW-A3R5	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7069
p.S279N	DO37406	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7069
p.R886H	TCGA-GV-A3QI	BLCA	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.R886H	DO470	BLCA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.3056
p.P875T	TCGA-IN-A6RO	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.2222
p.P875T	DO51740	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.2222
p.L287V	TCGA-TM-A7CF	LGG	TCGA	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.L287V	DO50229	LGG	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1389
p.Y873C	TCGA-VQ-A8P2	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation blocking phosphorylation signal	0.6111
p.Y873C	DO51761	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation blocking phosphorylation signal	0.6111
p.V270M	DO234192	ESAD	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.G890C	DO233624	GACA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.1944
p.D892Y	DO228985	LICA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation rewiring degron network	0.1389
p.G284V	DO229034	LICA	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.2222
p.Y880C	DO23238	LINC	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	879:885	Mutation altering degron motif	0.7087
p.P288L	DO23240	LINC	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.P288L	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.P288L	ACH-001738	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1111
p.P276L	DO232532	PBCA	ICGC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation altering degron motif	0.7582
p.T286A	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00656	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00087	Plasma Cell Myeloma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00846	Cervical Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01112	Osteosarcoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00878	Breast Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00793	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00760	Small Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00785	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01318	Hepatocellular Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM00641	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01664	Prostate Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.T286A	SIDM01525	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.1667
p.R266H	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.R266H	ACH-002256	Leukemia	CCLE	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556
p.R266H	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	276:280	Mutation rewiring degron network	0.0556

Kaplan plot for THRAP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THRAP3

UniProt ID: Q9Y2W1

Entrez ID: 9967

Protein name: Thyroid hormone receptor-associated protein 3 (BCLAF1 and THRAP3 family member 2) (Thyroid hormone receptor-associated protein complex 150 kDa component) (Trap150)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THRAP3 in