DegronMD

Uniprot ID: Q9Y2W1

Source protein: Thyroid hormone receptor-associated protein 3

Source gene: THRAP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 879:885

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 93.0143

COIL: 0.7413

CONS_SCORE: 0.9208

DSS_SCORE: 0.5191

HELIX: 0.0813

FCONS_SCORE: 1.044

RIG_SCORE: 0.7527

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y880C	DO23238	LINC	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.7087
p.Y873C	TCGA-VQ-A8P2	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.6111
p.Y873C	DO51761	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.6111
p.R886C	TCGA-CG-5733	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R886C	DO38551	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R886H	TCGA-GV-A3QI	BLCA	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R886H	DO470	BLCA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P875T	TCGA-IN-A6RO	STAD	TCGA	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P875T	DO51740	STAD	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.2222
p.G890C	DO233624	GACA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D892Y	DO228985	LICA	ICGC	KYYLHDD	LIG_APCC_ABBAyCdc20_2	0.1389

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2W1	Thyroid hormone receptor-associated protein 3	LIG_APCC_ABBAyCdc20_2	879:885	KYYLHDD	APC,CDC20,FZR1	0.9846	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons