DegronMD - O15550(KDM6A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S580N	TCGA-AP-A1E0	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7069
p.S580N	DO43154	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7069
p.S582A	TCGA-B5-A3FA	UCEC	TCGA	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7588
p.S582A	DO52402	UCEC	ICGC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7588
p.F572C	TCGA-EA-A3HU	CESC	TCGA	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.F572C	DO6320	CESC	ICGC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.Q667K	TCGA-ER-A19H	SKCM	TCGA	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222
p.Q667K	DO47299	SKCM	ICGC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222
p.Q670R	DO222427	BTCA	ICGC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1389
p.A671E	DO50681	ORCA	ICGC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.T584M	SIDM00663	Melanoma	GDSC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2778
p.I591V	SIDM00845	Burkitt's Lymphoma	GDSC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.I591V	ACH-000786	Lymphoma	CCLE	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.I591V	ACH-000992	Head and Neck Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.I591V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.S651L	SIDM00845	Burkitt's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651L	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651L	SIDM01519	Head and Neck Carcinoma	GDSC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651L	ACH-000786	Lymphoma	CCLE	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.S651L	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1111
p.N569D	SIDM01608	Endometrial Carcinoma	GDSC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.N569D	ACH-000990	Endometrial/Uterine Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.0833
p.G653D	ACH-000353	Esophageal Cancer	CCLE	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.1667
p.A574E	ACH-000520	Ovarian Cancer	CCLE	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.H664Q	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.3056
p.H664Q	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.3056
p.I673T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.I673T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.0556
p.Q578P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7035
p.Q578P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7035
p.I574V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.P584H	OVK-18	ovary	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2778
p.S582L	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7667
p.S582L	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7667
p.I581V	Daudi	haematopoietic and lymphoid tissue	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7076
p.G577C	HEC-1	endometrium	COSMIC	PCSTS	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.I655T	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222
p.I655T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	659:663	Mutation rewiring degron network	0.2222

Kaplan plot for KDM6A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KDM6A

UniProt ID: O15550

Entrez ID: 7403

Protein name: Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KDM6A in